CAJ | 학술논문

目的：观察芪胶升白胶囊对恶性消化道肿瘤化疗后骨髓抑制及免疫状态的影响。方法将140例患者随机编为两组，治疗组（化疗＋芪胶升白胶囊），72例；对照组（单纯化疗组）68例。比较化疗前后两组患者生活质量、骨髓抑制、血淋巴细胞百分比、血Th1和Th2类细胞因子表达水平。结果治疗组生活质量提高率37．5％，对照组20．6％，P＜0．05；治疗组化疗后Ⅱ度以上骨髓抑制发生率低于对照组（P＜0．05）；治疗组化疗后淋巴细胞百分含量及比值较对照组增高明显（P＜0．05）。治疗后Th1类细胞因子表达水平状况分析，治疗组高于本组治疗前及对照组化疗后的表达水平（P＜0．05）；治疗后，治疗组Th2类细胞因子的表达水平明显低于治疗前及对照组化疗后（P＜0．05）。结论芪胶升白胶囊可提高患者生活质量，降低化疗所产生的骨髓毒性，起到改善患者细胞免疫状态的作用。
목적：관찰기효승백효낭대악성소화도종류화료후골수억제급면역상태적영향。방법장140례환자수궤편위량조，치료조（화료＋기효승백효낭），72례；대조조（단순화료조）68례。비교화료전후량조환자생활질량、골수억제、혈림파세포백분비、혈Th1화Th2류세포인자표체수평。결과치료조생활질량제고솔37．5％，대조조20．6％，P＜0．05；치료조화료후Ⅱ도이상골수억제발생솔저우대조조（P＜0．05）；치료조화료후림파세포백분함량급비치교대조조증고명현（P＜0．05）。치료후Th1류세포인자표체수평상황분석，치료조고우본조치료전급대조조화료후적표체수평（P＜0．05）；치료후，치료조Th2류세포인자적표체수평명현저우치료전급대조조화료후（P＜0．05）。결론기효승백효낭가제고환자생활질량，강저화료소산생적골수독성，기도개선환자세포면역상태적작용。
Objective To observe the effect of Qijiaoshenbai capsule on bone marrow suppression and immune state of malignant gastrointestinal tumor after chemotherapy .Methods 140 patients were randomly divided into 2 groups,the treatment group (chemotherapy and Qijiaoshenbai capsules ),72 cases;the control group (chemotherapy ),68 cases.Living quality of pa-tients,bone marrow suppression,the percentage of blood lymphocytes ,and the expression levels of plasma Th1、Th2 type cytokines of the 2 groups before and after chemotherapy were compared .Results The improvement of living quality of the treatment group was 37.5%,and 20.6%in the control group ,P<0.05;bone marrow suppression rate overⅡ degree in the treatment group was lower than that of the control group after chemotherapy ( P-values<0.05);the lymphocyte percentage and ratio of the treatment group increased significantly compared with the control group after chemotherapy (P<0.05).The expression level of plasma Th1 type cytokines in the treatment group after treatment were higher than before treatment , and was higher than that of the control group after chemotherapy(P<0.05);The expression level of plasma Th2 type cytokines in the treatment group after treatment were significantly lower than before treatment ,and was lower than that of the control group after chemotherapy (P<0.05).Con-clusion Qijiaoshenbai capsule can efficiently enhance the living quality of patients , reduce the toxicity of bone marrow after chemotherapy ,and improve the cellular immune state of patients .