实用癌症杂志
實用癌癥雜誌
실용암증잡지
The Practical Journal of Cancer
2015年
10期
1434-1438
,共5页
异常糖链糖蛋白%常见消化道癌%筛查%早期诊断%发生率
異常糖鏈糖蛋白%常見消化道癌%篩查%早期診斷%髮生率
이상당련당단백%상견소화도암%사사%조기진단%발생솔
Tumor abnormal protein%Common gastrointestinal cancers (CGICs)%Screening%Early diagnosis%Incidence
目的：探讨异常糖链糖蛋白（ TAP）对常见消化道癌（ CGICs）筛查的临床意义。方法将400例入选对象分为4个组：CGICs高危人群组、CGICs患者组、BGIDs患者组及正常人群组，每组100例；检测4组入院时、手术后2周时TAP、微磁（ OWMF）的表达水平，并随访2年、动态监测TAP表达的变化。结果①CGICs高危人群组、CGICs患者组以及正常人群组TAP阳性表达率分别为39．00％、92．00％及3．00％，3组间差异明显（ P＜0．01）；②TAP检测对消化道癌诊断的Sen、Spe、β、α、YI、﹢PV、﹣PV以及OCR分别为92．00％、84．33％、8．00％、15．67％、0．7633、66．18％、96．93％以及86．25％；③随访2年后， CGICs 高危人群组、消化道良性病组并正常人群组TAP 阳性病例CGICs 发生率分别为28．21％和12．50％，明显高于TAP阴性病例的4．92％和0（P＜0．01）；④随访2后年，CGICs组术后TAP阳性病例CGICs复发率为37．04％比TAP阴性病例（6．85％）明显增高（ P＜0．01）。结论 TAP检测是常见消化道癌筛查、早期诊断及预后判断的科学、有效的方法。
目的：探討異常糖鏈糖蛋白（ TAP）對常見消化道癌（ CGICs）篩查的臨床意義。方法將400例入選對象分為4箇組：CGICs高危人群組、CGICs患者組、BGIDs患者組及正常人群組，每組100例；檢測4組入院時、手術後2週時TAP、微磁（ OWMF）的錶達水平，併隨訪2年、動態鑑測TAP錶達的變化。結果①CGICs高危人群組、CGICs患者組以及正常人群組TAP暘性錶達率分彆為39．00％、92．00％及3．00％，3組間差異明顯（ P＜0．01）；②TAP檢測對消化道癌診斷的Sen、Spe、β、α、YI、﹢PV、﹣PV以及OCR分彆為92．00％、84．33％、8．00％、15．67％、0．7633、66．18％、96．93％以及86．25％；③隨訪2年後， CGICs 高危人群組、消化道良性病組併正常人群組TAP 暘性病例CGICs 髮生率分彆為28．21％和12．50％，明顯高于TAP陰性病例的4．92％和0（P＜0．01）；④隨訪2後年，CGICs組術後TAP暘性病例CGICs複髮率為37．04％比TAP陰性病例（6．85％）明顯增高（ P＜0．01）。結論 TAP檢測是常見消化道癌篩查、早期診斷及預後判斷的科學、有效的方法。
목적：탐토이상당련당단백（ TAP）대상견소화도암（ CGICs）사사적림상의의。방법장400례입선대상분위4개조：CGICs고위인군조、CGICs환자조、BGIDs환자조급정상인군조，매조100례；검측4조입원시、수술후2주시TAP、미자（ OWMF）적표체수평，병수방2년、동태감측TAP표체적변화。결과①CGICs고위인군조、CGICs환자조이급정상인군조TAP양성표체솔분별위39．00％、92．00％급3．00％，3조간차이명현（ P＜0．01）；②TAP검측대소화도암진단적Sen、Spe、β、α、YI、﹢PV、﹣PV이급OCR분별위92．00％、84．33％、8．00％、15．67％、0．7633、66．18％、96．93％이급86．25％；③수방2년후， CGICs 고위인군조、소화도량성병조병정상인군조TAP 양성병례CGICs 발생솔분별위28．21％화12．50％，명현고우TAP음성병례적4．92％화0（P＜0．01）；④수방2후년，CGICs조술후TAP양성병례CGICs복발솔위37．04％비TAP음성병례（6．85％）명현증고（ P＜0．01）。결론 TAP검측시상견소화도암사사、조기진단급예후판단적과학、유효적방법。
Objective To investigate the clinical significance of tumor abnormal protein ( TAP) in the screening of com-mon gastrointestinal cancers (CGICs).Methods 400 cases were divided into 4 groups,high risk CGICs,CGICs patients,BGIDs patients and the normal group ,100 cases in each .The expression levels of TAP and OWMF in the 4 groups were tested at admis-sion and 2 weeks after operation .In 2-year follow-up,the dynamic variations of TAP expression were monitored .Results ①The positive expression rates of TAP were 39.00%,92.00%and 3.00%in high CGICs risk group ,CGICs group and normal group , respectively,showed significant difference (P<0.01).②In detection of TAP,the values of Sen,Spe,β,α,YI,+PV,+PV and OCR yielded to gastrointestinal cancer diagnosis were 92.00%,84.33%,8.00%,15.67%,0.7633,66.18%,96.93% and 86.25%,respectively.③After 2-year follow-up,the incidence of CGICs in the TAP positive cases of high CGICs risk group and the combined group of benign gastrointestinal disease and normal controls was 28.21% and 12.50%,respectively,which were significant (P<0.01)higher than those of TAP negative cases (4.92%and 0).④ In the CGICs group,the recurrence rate of CGICs in cases showing TAP positive postoperative was 37.04%after 2-year follow-up,which was significantly ( P<0.01) high-er than that of TAP negative cases (6.85%).Conclusion Detection of TAP is a scientific and effective method in screening , early diagnosis and prognosis of CGICs .
