CAJ | 학술논문

目的：探讨131 I（清甲）治疗对分化型甲状腺癌患者术后复发的影响。方法按照患者是否愿意接受131 I （清甲）治疗将137例分化型甲状腺癌患者分为实验组（接受131 I治疗）71例和对照组（不接受131 I治疗）66例，实验组患者术后给予131 I（清甲）＋甲状腺素替代治疗，对照组患者术后仅给予甲状腺素替代治疗，比较两组患者术后2年随访期间甲状腺球蛋白（ TG）水平变化情况以及复发情况。结果实验组患者术后6、12、18、24个月TG水平均显著低于对照组，差异具有统计学意义（ P＜0．05）；对照组患者术后18、24个月TG水平均显著高于术后6和12个月，术后24个月TG水平均显著高于术后6个月、12个月、18个月，差异具有统计学意义（ P＜0．05）；实验组患者术后2年复发率显著低于对照组，差异具有统计学意义（P＜0．05）。结论分化型甲状腺癌术后采取131 I（清甲）治疗，能够有效改善患者甲状腺功能，降低复发率，临床效果显著。
목적：탐토131 I（청갑）치료대분화형갑상선암환자술후복발적영향。방법안조환자시부원의접수131 I （청갑）치료장137례분화형갑상선암환자분위실험조（접수131 I치료）71례화대조조（불접수131 I치료）66례，실험조환자술후급여131 I（청갑）＋갑상선소체대치료，대조조환자술후부급여갑상선소체대치료，비교량조환자술후2년수방기간갑상선구단백（ TG）수평변화정황이급복발정황。결과실험조환자술후6、12、18、24개월TG수평균현저저우대조조，차이구유통계학의의（ P＜0．05）；대조조환자술후18、24개월TG수평균현저고우술후6화12개월，술후24개월TG수평균현저고우술후6개월、12개월、18개월，차이구유통계학의의（ P＜0．05）；실험조환자술후2년복발솔현저저우대조조，차이구유통계학의의（P＜0．05）。결론분화형갑상선암술후채취131 I（청갑）치료，능구유효개선환자갑상선공능，강저복발솔，림상효과현저。
Objective To explore the effect of 131 I on postoperative recurrence of differentiated thyroid carcinoma .Meth-ods 137 cases of differentiated thyroid carcinoma were divided into the experimental group (71 cases) and the control group(66 cases).The experiment group were treated by 131I+thyroid hormone replacement therapy.The control group were treated by thy-roid hormone replacement therapy .The levels of TG and recurrence of the 2 groups during 2-year follow-up were compared .Re-sults The levels of TG 6 months,12 months,18 months,24 months after surgery in the experimental group were lower than those of the control group(P<0.05);The levels of TG 18 months,24 months after surgery in the control group were higher than those of 6 months,12 months after surgery(P<0.05);The levels of TG 24 months after surgery were higher than that of 6 months,12 months,18 months after surgery(P<0.05).The rate of recurrence in the experiment group 2 years after surgery were lower than that of the control group(P<0.05).Conclusion 131I for differentiated thyroid carcinoma can improve thyroid function ,and re-duce the recurrence rate .It has obvious clinical effect .