CAJ | 학술논문

目的：探讨替吉奥联合紫杉醇治疗晚期胃癌的疗效及不良反应。方法将92例胃癌晚期患者依据治疗方法分为替吉奥联合紫杉醇治疗组（观察组）和传统常规治疗组（对照组）。比较2组治疗的临床疗效和不良反应情况。结果观察组有效率为52．17％（24／46），对照组有效率为43．48％，2组差异具有统计学意义（P＜0．05）。观察组患者在治疗过程中产生的不良反应少于对照组，差异具有统计学意义（P＜0．05）。结论替吉奥联合紫杉醇治疗晚期胃癌的疗效相对明显，且产生的毒副作用明显少于传统治疗方法。
목적：탐토체길오연합자삼순치료만기위암적료효급불량반응。방법장92례위암만기환자의거치료방법분위체길오연합자삼순치료조（관찰조）화전통상규치료조（대조조）。비교2조치료적림상료효화불량반응정황。결과관찰조유효솔위52．17％（24／46），대조조유효솔위43．48％，2조차이구유통계학의의（P＜0．05）。관찰조환자재치료과정중산생적불량반응소우대조조，차이구유통계학의의（P＜0．05）。결론체길오연합자삼순치료만기위암적료효상대명현，차산생적독부작용명현소우전통치료방법。
Objective To investigate the efficacy and adverse reactions of S-1 combined with paclitaxel for patients with advanced gastric cancer .Methods 92 patients with advanced gastric cancer patients ,according to treatment methods ,were divid-ed into S-1 plus paclitaxel group ( observation group ) and traditional conventional treatment group ( control group ) .Clinical effi-cacy and adverse reactions of the 2 groups were compared .Results The effective rate in the observation group was 52.17%(24/46),and that of the control group was 43.48%,there had statistically significant difference between the 2 groups (P<0.05).Adverse reactions in the observation group was less than that of the control group ,the difference was statistically significant (P<0.05).Conclusion S-1 combined with paclitaxel for advanced gastric cancer is effective ,and the side effects is less than traditional treatment methods .