中华普通外科学文献（电子版）
中華普通外科學文獻（電子版）
중화보통외과학문헌（전자판）
Chinese Archives of General Surgery(Electronic Edition)
2015年
5期
356-359
,共4页
陈强%谢庆吉%岑宏%汤聪
陳彊%謝慶吉%岑宏%湯聰
진강%사경길%잠굉%탕총
甲状腺乳头状癌%PAK1%免疫组化
甲狀腺乳頭狀癌%PAK1%免疫組化
갑상선유두상암%PAK1%면역조화
Papillary thyroid carcinoma%P21 activated kinase 1%Immunohistochemistry
目的 探讨甲状腺乳头状癌(PTC)中P21激活激酶1(PAK1)的表达情况及其临床意义. 方法 使用免疫组化法检测55例PTC和25例非恶性甲状腺组织中PAK1蛋白的表达情况,分析其与PTC临床病理参数的关系.结果 43.6%(24/55)的PTC组织中PAK1蛋白高表达或过表达,显著高于甲状腺良性组织的8.0%(2/25)(x2=9.950,P=0.002).在有腺体外浸润﹑临床分期较高﹑有淋巴结转移的PTC中PAK1蛋白的表达较高,差异均有统计学意义(x2=5.832,P=0.016; 2=4.448,P=0.035;x2=4.990,P=0.025);而在不同年龄﹑性别﹑肿瘤大小﹑是否多发﹑是否为双侧等分组中差异均无统计学意义. 结论 PAK1在PTC中呈高表达,可能参与肿瘤增殖﹑浸润和转移.
目的 探討甲狀腺乳頭狀癌(PTC)中P21激活激酶1(PAK1)的錶達情況及其臨床意義. 方法 使用免疫組化法檢測55例PTC和25例非噁性甲狀腺組織中PAK1蛋白的錶達情況,分析其與PTC臨床病理參數的關繫.結果 43.6%(24/55)的PTC組織中PAK1蛋白高錶達或過錶達,顯著高于甲狀腺良性組織的8.0%(2/25)(x2=9.950,P=0.002).在有腺體外浸潤﹑臨床分期較高﹑有淋巴結轉移的PTC中PAK1蛋白的錶達較高,差異均有統計學意義(x2=5.832,P=0.016; 2=4.448,P=0.035;x2=4.990,P=0.025);而在不同年齡﹑性彆﹑腫瘤大小﹑是否多髮﹑是否為雙側等分組中差異均無統計學意義. 結論 PAK1在PTC中呈高錶達,可能參與腫瘤增殖﹑浸潤和轉移.
목적 탐토갑상선유두상암(PTC)중P21격활격매1(PAK1)적표체정황급기림상의의. 방법 사용면역조화법검측55례PTC화25례비악성갑상선조직중PAK1단백적표체정황,분석기여PTC림상병리삼수적관계.결과 43.6%(24/55)적PTC조직중PAK1단백고표체혹과표체,현저고우갑상선량성조직적8.0%(2/25)(x2=9.950,P=0.002).재유선체외침윤﹑림상분기교고﹑유림파결전이적PTC중PAK1단백적표체교고,차이균유통계학의의(x2=5.832,P=0.016; 2=4.448,P=0.035;x2=4.990,P=0.025);이재불동년령﹑성별﹑종류대소﹑시부다발﹑시부위쌍측등분조중차이균무통계학의의. 결론 PAK1재PTC중정고표체,가능삼여종류증식﹑침윤화전이.
Objective To investigate the expression of P21 activated kinase 1 (PAK1) protein in papillary thyroid carcinoma (PTC), and to figure out its clinical significance. Methods We used strept a-vidin-biotin complex (SABC), the sensitive immunohistochemistry, to detect the expression of PAK1 in eighty paraffin-embedded specimens, including 55 PTC and 25 benign thyroid nodules, and to explore its relationship with clinicopathological characteristics of PTC. Results 43.6% of PTC specimens showed significantly higher expression of PAK1 protein than that of benign lesions of thyroid, which had only 8.0% positive expression rate (x2=9.950, P=0.002). The expression of PAK1 was positively and signifi-cantly correlated with tumor invasion, advanced stage and lymph node metastasis (x2=5.832, P=0.016;x2=4.448, P=0.035;x2=4.990, P=0.025), but it had no correlation with age, gender, tumor size, multiple tu-mors and bilateral tumors in PTC. Conclusion The high expression of PAK1 in PTC is related to the possibility of proliferation, invasion and lymph node metastasis.
