当代医学
噹代醫學
당대의학
Contemporary Medicine
2015年
29期
6-8
,共3页
N末端脑钠肽原%降钙素原%川崎病
N末耑腦鈉肽原%降鈣素原%川崎病
N말단뇌납태원%강개소원%천기병
NT-pro BNP%PCT%Kawasaki disease
目的 探讨血浆N末端脑钠肽原(N-pro-BNP)及降钙素原在早期诊断川崎病及预测其心血管损害中的意义.方法 选取46例川崎病患儿作为观察组,并根据患儿的心脏彩超及心电图结果进行分组,将其分为心血管损害组和无心血管损害组.同时选取健康体检儿童21名作为正常对照组.采集各组血清,采用化学发光法技术测定血浆N末端脑钠肽原及降钙素原的表达水平.结果 川崎病患儿血浆中BNP水平为(710.526±757.668) ng/mL,而对照组患儿血浆中BNP水平为(66.226±18.443)ng/mL,川崎病患儿血浆中N末端脑钠肽的水平显著高于对照组(P<0.05).川崎病患儿血浆中PCT水平为(2.677±8.165)ng/mL,而对照组患儿血浆中PCT水平为(0.208±0.085)ng/mL,川崎病患儿血浆中PCT水平显著高于对照组(P<0.05).在川崎病患儿中,心血管损害组的BNP水平为(1345.785±534.590)ng/mL,无心血管损害组的BNP水平为(167.812±75.644)ng/mL,心血管损害组患儿血浆中BNP水平显著高于无心血管损害组(P<0.05);心血管损害组的PCT水平为(4.250±11.388)ng/mL,无心血管损害组的PCT水平为(0.771±2.092)ng/mL,心血管损害组患儿PCT水平显著高于无心血管损害组(P<0.05).结论 血浆N末端脑钠肽原及降钙素原在早期诊断川崎病及预测心血管损害方面有重要的意义,为诊断川崎病及时使用丙种球蛋白提供理论依据,以减少川崎病患儿冠状动脉的损害,保护患儿身心健康.
目的 探討血漿N末耑腦鈉肽原(N-pro-BNP)及降鈣素原在早期診斷川崎病及預測其心血管損害中的意義.方法 選取46例川崎病患兒作為觀察組,併根據患兒的心髒綵超及心電圖結果進行分組,將其分為心血管損害組和無心血管損害組.同時選取健康體檢兒童21名作為正常對照組.採集各組血清,採用化學髮光法技術測定血漿N末耑腦鈉肽原及降鈣素原的錶達水平.結果 川崎病患兒血漿中BNP水平為(710.526±757.668) ng/mL,而對照組患兒血漿中BNP水平為(66.226±18.443)ng/mL,川崎病患兒血漿中N末耑腦鈉肽的水平顯著高于對照組(P<0.05).川崎病患兒血漿中PCT水平為(2.677±8.165)ng/mL,而對照組患兒血漿中PCT水平為(0.208±0.085)ng/mL,川崎病患兒血漿中PCT水平顯著高于對照組(P<0.05).在川崎病患兒中,心血管損害組的BNP水平為(1345.785±534.590)ng/mL,無心血管損害組的BNP水平為(167.812±75.644)ng/mL,心血管損害組患兒血漿中BNP水平顯著高于無心血管損害組(P<0.05);心血管損害組的PCT水平為(4.250±11.388)ng/mL,無心血管損害組的PCT水平為(0.771±2.092)ng/mL,心血管損害組患兒PCT水平顯著高于無心血管損害組(P<0.05).結論 血漿N末耑腦鈉肽原及降鈣素原在早期診斷川崎病及預測心血管損害方麵有重要的意義,為診斷川崎病及時使用丙種毬蛋白提供理論依據,以減少川崎病患兒冠狀動脈的損害,保護患兒身心健康.
목적 탐토혈장N말단뇌납태원(N-pro-BNP)급강개소원재조기진단천기병급예측기심혈관손해중적의의.방법 선취46례천기병환인작위관찰조,병근거환인적심장채초급심전도결과진행분조,장기분위심혈관손해조화무심혈관손해조.동시선취건강체검인동21명작위정상대조조.채집각조혈청,채용화학발광법기술측정혈장N말단뇌납태원급강개소원적표체수평.결과 천기병환인혈장중BNP수평위(710.526±757.668) ng/mL,이대조조환인혈장중BNP수평위(66.226±18.443)ng/mL,천기병환인혈장중N말단뇌납태적수평현저고우대조조(P<0.05).천기병환인혈장중PCT수평위(2.677±8.165)ng/mL,이대조조환인혈장중PCT수평위(0.208±0.085)ng/mL,천기병환인혈장중PCT수평현저고우대조조(P<0.05).재천기병환인중,심혈관손해조적BNP수평위(1345.785±534.590)ng/mL,무심혈관손해조적BNP수평위(167.812±75.644)ng/mL,심혈관손해조환인혈장중BNP수평현저고우무심혈관손해조(P<0.05);심혈관손해조적PCT수평위(4.250±11.388)ng/mL,무심혈관손해조적PCT수평위(0.771±2.092)ng/mL,심혈관손해조환인PCT수평현저고우무심혈관손해조(P<0.05).결론 혈장N말단뇌납태원급강개소원재조기진단천기병급예측심혈관손해방면유중요적의의,위진단천기병급시사용병충구단백제공이론의거,이감소천기병환인관상동맥적손해,보호환인신심건강.
Objective To explore the expression of N-pro-BNP and PCT in kawasaki disease,and discuss their significance value in the coronary artery lesion(CLA) with kawasaki disease.Methods 46 cases of KD were drawn as observation group, in which 24 patients developed with coronary artery lesion, other 23 patients with normal coronary artery. Meanwhile, 21 normal cases were selected as normal control group. Blood samples were collected. BNP and PCT levels were detected by chemiluminescence. We analyzed all the data with SPSS 20.0 for Windows.Results The mean plasma BNP concentration in patients with KD was(710.526±757.668)ng/mL, but was (66.226±18.443)ng/mL in patients of control. The plasma BNP contention in patients with KD was significantly higher than that of the control group(P<0.05). The mean PCT concentration in patients with KD was(2.677±8.165)ng/ml, and was(0.208±0.085)ng/mL in patients of control. The plasma PCT contention in patients with KD was significantly higher than that of the control group(P<0.05).During the KD group, patients developed with coronary artery lesion. The leavel of BNP in patients with coronary artery lesion was(1345.785±534.590)ng/mL, but was (167.812±75.644)ng/mL in patients with normal coronary artery. The plasma BNP leavel in patients with coronary artery lesion was much higher than patients with normal coronary artery (P<0.05). The leavel of PCT in patients with coronary artery lesion was(4.250±11.388)ng/mL, but was(0.771±2.092)ng/mL in patients with normal coronary artery. The plasma PCT leavel in patients with coronary artery lesion was much higher than patients with normal coronary artery (P<0.05).Conclusion The plasma BNP and PCT may be useful in the early diognosis of KD, the level of plasma BNP and PCT can be used as biochemical marker of cardiac involvernent. This would be valuable for the diagnosis of KD, which would decrease the probability of coronary artery lesion.
