CAJ | 학술논문

目的：：分析术前外周血血钙水平和中性粒细胞淋巴细胞计数比(NLR)对肾癌预后判断的价值.方法：回顾2011全年经手术治疗的173例肾透明细胞癌患者的临床资料，分析影响肾透明细胞癌患者预后的相关因素，并在此基础上比较血钙下降组和正常组患者的生存情况.结果：单因素分析显示，术前血钙水平、NLR、术后肿瘤 TNM 分期及 Furhman 核分级是影响肾透明癌患者生存期的影响因素(均 P ＜0.05)；但多因素 Cox 回归分析提示，只有术后 TNM 分期和 Furhman 核分级为肾癌预后独立影响因素.进一步对血钙进行 Kaplan-Meier 生存曲线分析显示，下降组与正常组3年生存率分别为73.2％和93.6％，两组间差异有统计学意义(P ＜0.01).结论：术前血钙水平和 NLR 可作为肾透明细胞癌预后的有效指标.
목적：：분석술전외주혈혈개수평화중성립세포림파세포계수비(NLR)대신암예후판단적개치.방법：회고2011전년경수술치료적173례신투명세포암환자적림상자료，분석영향신투명세포암환자예후적상관인소，병재차기출상비교혈개하강조화정상조환자적생존정황.결과：단인소분석현시，술전혈개수평、NLR、술후종류 TNM 분기급 Furhman 핵분급시영향신투명암환자생존기적영향인소(균 P ＜0.05)；단다인소 Cox 회귀분석제시，지유술후 TNM 분기화 Furhman 핵분급위신암예후독립영향인소.진일보대혈개진행 Kaplan-Meier 생존곡선분석현시，하강조여정상조3년생존솔분별위73.2％화93.6％，량조간차이유통계학의의(P ＜0.01).결론：술전혈개수평화 NLR 가작위신투명세포암예후적유효지표.
Objective:To investigate the validation of preoperative blood calcium level and neutrophil/lymphocyte ratio (NLR)as prognostic indicators for clear cell renal cell carcinoma (ccRCC)after surgery.Methods:Data from 1 73 patients with ccRCC,treated within the whole year of 201 1 at a single center,were evaluated retrospectively. Preoperative NLR,the blood calcium level,TNM and Furhman staging were analyzed by using univariate analysis and Cox multivariate regression analysis respectively.Furthermore,according to the different preoperative blood cal-cium levels,the Kaplan-Meier method was used to compare the postoperative survivals between declined group and normal group.Results:Univariate analysis revealed that the high NLR,low blood calcium level,high TNM staging and high Furhman staging were identified as relative factors of overall survival (P <0.05 for all).However,Multi-variate analysis showed that TNM staging and Furhman staging were the independent prognostic factors (P <0.05). The 3-year survival rate in declined group and normal group was 73.2% and 93.6% respectively (P <0.01).Conclu-sions:We confirmed a significant association of preoperative elevated NLR and declined blood calcium level with poor clinical outcome in ccRCC patients.Our result indicate that preoperative NLR and blood calcium level could represent useful markers for patients'stratification in ccRCC management.