CAJ | 학술논문

目的研究胆道口(Oddi)括约肌运动功能在豚鼠胆囊胆固醇结石形成过程中的作用. 方法 34只成年雄性Hartley豚鼠随机分为胆固醇结石组(24只)和对照组(10只),其中胆固醇结石组(按被处死的时间,分为4个亚组,各6只)给予致石饮食,3﹑6﹑9﹑12周后对两组行胆道口括约肌测压并检测肌电活动. 结果胆固醇结石组3﹑6﹑9﹑12周的发生率分别为0﹑16.7%﹑16.7%﹑83.3%. 肌电活动的频率在3周组和6周组减小(均P<0.05),肌电活动幅度在9周组和12周组明显降低[从(146.44 ± 81.09)μV分别降至(68.18 ± 49.58)μV和(40.60 ±45.03)μV, P<0.05]. 胆道口括约肌收缩频率在6周组和9周组明显减小(P<0.05). 胆道口括约肌基础压及胆总管压在12周组明显升高[从(25.19 ± 7.77) mmHg至(52.38 ± 12.84) mmHg,(22.35 ± 7.60) mmHg至(50.11 ± 12.59) mmHg,均P<0.01]. 结论致胆固醇结石饮食能诱发胆道口括约肌功能紊乱,其张力增加﹑活动性下降.胆道口括约肌运动功能紊乱是胆色素结石形成的一个重要因素.
목적 연구담도구(Oddi)괄약기운동공능재돈서담낭담고순결석형성과정중적작용. 방법 34지성년웅성Hartley돈서수궤분위담고순결석조(24지)화대조조(10지),기중담고순결석조(안피처사적시간,분위4개아조,각6지)급여치석음식,3﹑6﹑9﹑12주후대량조행담도구괄약기측압병검측기전활동. 결과 담고순결석조3﹑6﹑9﹑12주적발생솔분별위0﹑16.7%﹑16.7%﹑83.3%. 기전활동적빈솔재3주조화6주조감소(균P<0.05),기전활동폭도재9주조화12주조명현강저[종(146.44 ± 81.09)μV분별강지(68.18 ± 49.58)μV화(40.60 ±45.03)μV, P<0.05]. 담도구괄약기수축빈솔재6주조화9주조명현감소(P<0.05). 담도구괄약기기출압급담총관압재12주조명현승고[종(25.19 ± 7.77) mmHg지(52.38 ± 12.84) mmHg,(22.35 ± 7.60) mmHg지(50.11 ± 12.59) mmHg,균P<0.01]. 결론 치담고순결석음식능유발담도구괄약기공능문란,기장력증가﹑활동성하강.담도구괄약기운동공능문란시담색소결석형성적일개중요인소.
Objective To investigate the role of Oddi sphincter motility in cholesterol gallbladder stone formation in model of guinea pigs. Methods Thirty-four adult male Hartley guinea pigs were divided randomly into two groups, control group (10 guinea pigs) and cholesterol stone groups (divided into 4 subgroups with 6 guinea pigs in each according to time they were sacrificed). The animals in cholesterol stone groups were fed with cholesterol lithogenic diet and sacrificed after 3, 6, 9 and 12 weeks. Sphincter of Oddi manometry and recording of myoelectric activity of the guinea pigs were obtained by multifunctional physiograph at each stage. Results The incidence of cholesterol gallstone formation was 0, 16.7%, 16.7% and 83.3% in 3 w, 6 w, 9 w and 12 w group. The frequency of myoelectric activity decreased apparently in the 3 w group and 6 w group (P<0.05). The amplitude of myoelectric activity decreased apparently, from (146.44±81.09) μV to (68.18±49.58) μV and (40.60±45.03) μV in the 9 w group and the 12 w group (P<0.05). The frequency of Oddi sphincter decreased apparently in the 6 w and 9 w group (P<0.05). The Oddi sphincter basal pressure and common bile duct pressure increased apparently in the 12 w group, from (25.19±7.77) mmHg to (52.38±12.84) mmHg and from (22.35±7.60) mmHg to (50.11±12.59) mmHg, respectively (P<0.01). Conclusions Cholesterol gallstone-causing diet can induce dysfunction of Oddi sphincter, the tension increased and its activity decreased. The disturbance of Oddi sphincter motility plays an important role in cholesterol gallstone formation.