中华消化外科杂志
中華消化外科雜誌
중화소화외과잡지
Chinese Journal of Digestive Surgery
2015年
10期
877-880
,共4页
胆囊肿瘤%microRNAs%肿瘤发生%转移%预后
膽囊腫瘤%microRNAs%腫瘤髮生%轉移%預後
담낭종류%microRNAs%종류발생%전이%예후
Gallbladder neoplasms%MicroRNAs%Tumor genesis%Metastasis%Prognosis
微小RNA(miRNAs)是一类长度为18 ～ 25个核苷酸的内源性单链小分子非编码RNA,通过与靶蛋白mRNA 3 '端非编码区互补结合,抑制mRNA转录后靶蛋白的表达或通过降解mRNA调节特定基因的表达.其在细胞的增殖、分化和凋亡等方面发挥重要的生理作用.运用实验生物学及生物信息学方法对与肿瘤相关的miRNAs进行研究成为当前的热点.笔者主要介绍miRNAs在胆囊癌的发生、发展、转移及预后中的作用.
微小RNA(miRNAs)是一類長度為18 ～ 25箇覈苷痠的內源性單鏈小分子非編碼RNA,通過與靶蛋白mRNA 3 '耑非編碼區互補結閤,抑製mRNA轉錄後靶蛋白的錶達或通過降解mRNA調節特定基因的錶達.其在細胞的增殖、分化和凋亡等方麵髮揮重要的生理作用.運用實驗生物學及生物信息學方法對與腫瘤相關的miRNAs進行研究成為噹前的熱點.筆者主要介紹miRNAs在膽囊癌的髮生、髮展、轉移及預後中的作用.
미소RNA(miRNAs)시일류장도위18 ～ 25개핵감산적내원성단련소분자비편마RNA,통과여파단백mRNA 3 '단비편마구호보결합,억제mRNA전록후파단백적표체혹통과강해mRNA조절특정기인적표체.기재세포적증식、분화화조망등방면발휘중요적생리작용.운용실험생물학급생물신식학방법대여종류상관적miRNAs진행연구성위당전적열점.필자주요개소miRNAs재담낭암적발생、발전、전이급예후중적작용.
MicroRNAs are a kind of small endogenous non-protein-coding single-stranded RNA,which are 18 to 25 nucleotides long.They either regulate expression of specific genes through the degradation of mRNA or repress expression of target protein of mRNA postoperation by binding with the 3' untranslated region of targeting mRNAs.It produces important physiological effects on cell proliferation, differentiation and apoptosis.The use of experimental biology and bioinformatics methods for research of tumor-associated miRNAs has become research focus.In this paper, the role of miRNAs in the oncogenesis, development, metastasis and prognosis of gallbladder cancer is mainly introduced.
