中国医药指南
中國醫藥指南
중국의약지남
Guide of China Medicine
2015年
28期
8-9
,共2页
H-型高血压%冠心病%同型半胱氨酸%亚甲基四氢叶酸还原酶(MTHFR)
H-型高血壓%冠心病%同型半胱氨痠%亞甲基四氫葉痠還原酶(MTHFR)
H-형고혈압%관심병%동형반광안산%아갑기사경협산환원매(MTHFR)
H-type hypertension%Coronary heart disease%Homocysteine%MTHFR
目的：探讨H-型高血压患者中N5，N10-亚甲基四氢叶酸还原酶（MTHFR）C677T位点突变与血浆同型半胱氨酸（homocysteine， Hcy）及冠心病之间的关系。方法选择60例经冠状动脉造影的H-型高血压患者，分为冠心病组33例，非冠心病组27例，应用基因芯片技术检测2组MTHFR基因型，并比较2组MTHFR基因型分布及血浆Hcy水平。结果冠心病组的MTHFR基因CC型频率为27.3%， CT型频率为48.5%，TT型频率为24.2%。非冠心病组CC型频率为40.7%，CT型频率为48.2%，TT型频率为11.1%，冠心病组TT型基因及T等位基因频率高于非冠心病组，但是两组差异没有统计学意义（P＞0.05）。冠心病组的血浆平均Hcy浓度（19.82±16.2）μmol/L高于非冠心病组（15.78±5.63）μmol/L （P=0.022＜0.05），TT型的患者平均血浆Hcy浓度（32.58±23.06）μmol/L高于CC（14.64±6.93）μmol/L及CT（14.76±3.65）μmol/L组（P＜0.05），差异有统计学意义。结论 MTHFR基因多态性与H-型高血压患者冠心病的发生无明显相关性， MTHFR基因突变导致高同型半胱氨酸血症。高同型半胱氨酸血症是冠心病的独立危险因素。
目的：探討H-型高血壓患者中N5，N10-亞甲基四氫葉痠還原酶（MTHFR）C677T位點突變與血漿同型半胱氨痠（homocysteine， Hcy）及冠心病之間的關繫。方法選擇60例經冠狀動脈造影的H-型高血壓患者，分為冠心病組33例，非冠心病組27例，應用基因芯片技術檢測2組MTHFR基因型，併比較2組MTHFR基因型分佈及血漿Hcy水平。結果冠心病組的MTHFR基因CC型頻率為27.3%， CT型頻率為48.5%，TT型頻率為24.2%。非冠心病組CC型頻率為40.7%，CT型頻率為48.2%，TT型頻率為11.1%，冠心病組TT型基因及T等位基因頻率高于非冠心病組，但是兩組差異沒有統計學意義（P＞0.05）。冠心病組的血漿平均Hcy濃度（19.82±16.2）μmol/L高于非冠心病組（15.78±5.63）μmol/L （P=0.022＜0.05），TT型的患者平均血漿Hcy濃度（32.58±23.06）μmol/L高于CC（14.64±6.93）μmol/L及CT（14.76±3.65）μmol/L組（P＜0.05），差異有統計學意義。結論 MTHFR基因多態性與H-型高血壓患者冠心病的髮生無明顯相關性， MTHFR基因突變導緻高同型半胱氨痠血癥。高同型半胱氨痠血癥是冠心病的獨立危險因素。
목적：탐토H-형고혈압환자중N5，N10-아갑기사경협산환원매（MTHFR）C677T위점돌변여혈장동형반광안산（homocysteine， Hcy）급관심병지간적관계。방법선택60례경관상동맥조영적H-형고혈압환자，분위관심병조33례，비관심병조27례，응용기인심편기술검측2조MTHFR기인형，병비교2조MTHFR기인형분포급혈장Hcy수평。결과관심병조적MTHFR기인CC형빈솔위27.3%， CT형빈솔위48.5%，TT형빈솔위24.2%。비관심병조CC형빈솔위40.7%，CT형빈솔위48.2%，TT형빈솔위11.1%，관심병조TT형기인급T등위기인빈솔고우비관심병조，단시량조차이몰유통계학의의（P＞0.05）。관심병조적혈장평균Hcy농도（19.82±16.2）μmol/L고우비관심병조（15.78±5.63）μmol/L （P=0.022＜0.05），TT형적환자평균혈장Hcy농도（32.58±23.06）μmol/L고우CC（14.64±6.93）μmol/L급CT（14.76±3.65）μmol/L조（P＜0.05），차이유통계학의의。결론 MTHFR기인다태성여H-형고혈압환자관심병적발생무명현상관성， MTHFR기인돌변도치고동형반광안산혈증。고동형반광안산혈증시관심병적독립위험인소。
Objective To investigate the relationship between the gene polymorphism of N5,10-methylene tetrahydrofolate reductase (MTHFR) site-specific mulation C667T, homocysteine(Hcy) and coronary heart disease in H-type hypertension patients.Methods In this case-control study, we selected 60 H-type hypertension patients after Coronary angiography, Al patients were divided into two groups, CHD group(n=33)and non-CHD(n=27). To detected MTHFR C677T by gene chip technology, MTHFR genotype distributionb, the level of plasma Hcy was compared between the two groups.Results In CHD and non-CHD group,the frequencies of MTHFR C677T genotype were CC 27.3% vs 40.7%, CT 48.58% vs 48.2%, and TT 24.2% vs 11.1%. The frequency of T alele and TT homozygotes in MTHFR in CHD group was higher than that in non-CHD group, but there was no signiifcant difference between the two groups(P>0.05).②In CHD group, the plasma Hcy level(19.82±16.2)μmol/L was higher than that(15.78±5.63)μmol/L of the non-CHD group(P=0.022<0.05).③The plasma Hcy concentration of individuals with TT genotype(32.58±23.06)μmol/L was higher than that of individuals with CC(14.64±6.93)μmol/L and CT(14.76±3.65)μmol/L genotype(P<0.05).Conclusions The polymorphism of MTHFR C677T are not related to coronary heart disease in H-type hypertension patients. MTHFR gene mutations can lead to high homocysteine levels. HHcy were al independent risk factors of CHD.
