CAJ | 학술논문

目的：探讨针对创伤、严重脓毒症和多器官功能障碍综合征（MODS）患者开展免疫调理治疗的临床效果。方法选取本院2012年4月至2014年4月收治的创伤、严重脓毒症和MODS患者74例，采用随机数字法分为实验组与对照组各37例，对照组病例仅行ICU内常规治疗，实验组在其基础上增加免疫调理治疗方法。结果治疗后，两组患者的APACHEⅡ评分、IL-6、TNF-α、CD14+单核细胞HLA-DR表达水平以及存活率比较存在显著差异，具有统计学意义（P＜0.05）。结论针对创伤、严重脓毒血症和MODS患者采用免疫调理治疗可显著改善其机体免疫状况，提高治疗效果保证良好预后效果。
목적：탐토침대창상、엄중농독증화다기관공능장애종합정（MODS）환자개전면역조리치료적림상효과。방법선취본원2012년4월지2014년4월수치적창상、엄중농독증화MODS환자74례，채용수궤수자법분위실험조여대조조각37례，대조조병례부행ICU내상규치료，실험조재기기출상증가면역조리치료방법。결과치료후，량조환자적APACHEⅡ평분、IL-6、TNF-α、CD14+단핵세포HLA-DR표체수평이급존활솔비교존재현저차이，구유통계학의의（P＜0.05）。결론침대창상、엄중농독혈증화MODS환자채용면역조리치료가현저개선기궤체면역상황，제고치료효과보증량호예후효과。
Objective Discuss on clinical effects of Immune conditioning treatment of patients with trauma, severe sepsis and MODS.Methods Selected 74 patients with trauma, severe sepsis and MODS in our hospital from April 2012 to April 2014. Randomly divided into experimental group and control group(n=37). The patients in the control group only received the conventional treatment, the experimental group increased immune conditioning treatment on the basis.Results After treatment, the APACHEⅡ score, IL-6, TNF-α, CD14+ monocyte HLA-DR expression levels and survival rates signiifcant differences comparison of the two groups, had Statistical signiifcance (P<0.05).Conclusion Immune conditioning treatment of patients with trauma, severe sepsis and MODS can signiifcantly improve immune function, improve the therapeutic effect to ensure good prognosis effects.