CAJ | 학술논문

目的：观察贝那普利联合地尔硫卓治疗老年高血的临床疗效和安全性。方法入选老年原发性高血压患者100例，随机分为对照组（50例）和观察组（50例）。对照组采用贝那普利降压治疗，观察组采用贝那普利联合地尔硫卓降压治疗，疗程8周，每2周随访1次，观察收缩压、舒张压、心率、显效率、有效率、总有效率、降压达标率及不良反应。结果与对照组比较，8周后观察组收缩压、舒张压、心率较低，显效率、总有效率及降压达标率较高，差异有统计学意义（P＜0.05）；不良反应两组差异无统计学意义（P＞0.05）。结论贝那普利联合地尔硫卓能显著降低老年高血压患者的血压，耐受性良好，不良反应少。
목적：관찰패나보리연합지이류탁치료노년고혈적림상료효화안전성。방법입선노년원발성고혈압환자100례，수궤분위대조조（50례）화관찰조（50례）。대조조채용패나보리강압치료，관찰조채용패나보리연합지이류탁강압치료，료정8주，매2주수방1차，관찰수축압、서장압、심솔、현효솔、유효솔、총유효솔、강압체표솔급불량반응。결과여대조조비교，8주후관찰조수축압、서장압、심솔교저，현효솔、총유효솔급강압체표솔교고，차이유통계학의의（P＜0.05）；불량반응량조차이무통계학의의（P＞0.05）。결론패나보리연합지이류탁능현저강저노년고혈압환자적혈압，내수성량호，불량반응소。
Objective To observe the clinical efifcacy and safety of benazepril combined with diltialzem in elderly hypertention treatment.Method 100 elderly patients with essential hypertension were enrolled and randomly divided into control group (50 cases) and observation group (50 cases). The control group were treated by benazepril, and the observation group were treated by Benazepril combined with diltiazem. Systolic and diastolic blood pressure, heart rate, explicit efifciency, efifciency, total efifciency, antihypertensive compliance rate and adverse reactions were observed by follow-up one every two weeks. Result Compared with the control group, systolic and diastolic blood pressure, heart rate were lower, explicit efifciency, total efifciency and antihypertensive compliance rate were higher in observation group after 8 weeks, the difference was statistically signiifcant(P<0.05). Adverse reactions between two groups were not statistically signiifcant(P>0.05).Conclusion Benazepril combined with Diltiazem can signiifcantly reduce blood pressure, be well tolerated, and is fewer adverse reactions for elderly hypertensive patients.