国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
International Medicine and Health Guidance News
2015年
20期
3054-3057
,共4页
糖尿病视网膜病变%牛磺酸%糖化血红蛋白%总胆红素
糖尿病視網膜病變%牛磺痠%糖化血紅蛋白%總膽紅素
당뇨병시망막병변%우광산%당화혈홍단백%총담홍소
Diabetic retinopathy%Taurine%Glycosylated hemoglobin%Total bilirubin
目的 观察牛磺酸颗粒联合羟基磺酸钙对糖尿病视网膜病变(diabeticretinopathy,DR)的临床疗效,探讨药物作用与HbA1c、TBIL的关系.方法 选择门诊Ⅱ型DM单纯性DR患者63例,随机分为治疗组和对照组,治疗组使用牛磺酸加羟基磺酸钙联合治疗,对照组用羟基磺酸钙进行治疗,连续治疗6个月,采用眼底照相和FFA、视力判定疗效,HbA1c、TBIL水平分析药物与指标的关系.结果 总有效率对照组为61.29％,治疗组为81.25％,两组比较差异有统计学意义(P＜0.05);治疗后6个月治疗组HbA1c水平明显降低、TBIL明显升高,对照组HbA1c、TBIL无明显变化,两组比较差异有统计学意义(P＜0.05).结论 牛磺酸颗粒联合羟基磺酸钙可有效提高临床总有效率,连续口服4个月以上可降低HbA1c水平,提升TBIL水平,对DR治疗有正向促进作用.
目的 觀察牛磺痠顆粒聯閤羥基磺痠鈣對糖尿病視網膜病變(diabeticretinopathy,DR)的臨床療效,探討藥物作用與HbA1c、TBIL的關繫.方法 選擇門診Ⅱ型DM單純性DR患者63例,隨機分為治療組和對照組,治療組使用牛磺痠加羥基磺痠鈣聯閤治療,對照組用羥基磺痠鈣進行治療,連續治療6箇月,採用眼底照相和FFA、視力判定療效,HbA1c、TBIL水平分析藥物與指標的關繫.結果 總有效率對照組為61.29％,治療組為81.25％,兩組比較差異有統計學意義(P＜0.05);治療後6箇月治療組HbA1c水平明顯降低、TBIL明顯升高,對照組HbA1c、TBIL無明顯變化,兩組比較差異有統計學意義(P＜0.05).結論 牛磺痠顆粒聯閤羥基磺痠鈣可有效提高臨床總有效率,連續口服4箇月以上可降低HbA1c水平,提升TBIL水平,對DR治療有正嚮促進作用.
목적 관찰우광산과립연합간기광산개대당뇨병시망막병변(diabeticretinopathy,DR)적림상료효,탐토약물작용여HbA1c、TBIL적관계.방법 선택문진Ⅱ형DM단순성DR환자63례,수궤분위치료조화대조조,치료조사용우광산가간기광산개연합치료,대조조용간기광산개진행치료,련속치료6개월,채용안저조상화FFA、시력판정료효,HbA1c、TBIL수평분석약물여지표적관계.결과 총유효솔대조조위61.29％,치료조위81.25％,량조비교차이유통계학의의(P＜0.05);치료후6개월치료조HbA1c수평명현강저、TBIL명현승고,대조조HbA1c、TBIL무명현변화,량조비교차이유통계학의의(P＜0.05).결론 우광산과립연합간기광산개가유효제고림상총유효솔,련속구복4개월이상가강저HbA1c수평,제승TBIL수평,대DR치료유정향촉진작용.
Objective To observe the clinical efficacy of Taurine combined with hydroxy calcium sulfonate in simple diabetic retinopathy, to investigate the relationship between the drug and HbA1c, TBIL.Methods 63 patients with simple DR were randomly divided into treatment group and control group.Treatment group received Taurine and hydroxy calcium sulfonate, while control group received hydroxy calcium sulfonate, continuous treatment for 6 months.Evaluated clinical efficacy with fundus photography, FFA and vision, and analyzed the relationship between the drug and the levels of HbA1c, TBIL.Results The total effective rate in control group was 61.29％, that in treatment group was 81.25％, with statistically significant difference between two groups (P＜0.05).6 months after treatment, HbA1c in treatment group significantly lowered, TBIL significantly rose, while those in control group did not obviously changed, with statistically significant differences between two groups (P＜0.05).Conclusions Taurine combined with hydroxy calcium sulfonate can effectively improve the clinical total effective rate in patients with simple DR, continuous oral administration more than 4 months can reduce the level of HbA1c, increase the level of TBIL, as a positive role in promoting for the treatment of DR.
