CAJ | 학술논문

目的：观察妊娠期糖尿病孕妇的血清瘦素水平，分析血清瘦素与母婴预后之间的关系。方法选取我院确诊的42例GDM患者为研究对象，接受规范治疗的30例为治疗组，未治疗的12例作为未治疗组，随机抽取正常健康孕妇32例为正常对照组，在孕24～28周、孕38～40周分娩前、分娩后（脐动脉血）分别检测血清瘦素（ELISA法）和血糖，同时统计母婴并发症、婴儿出生体重、产后母体2型糖尿病患病率，并应用统计学软件对相关数据进行统计分析。结果在未进行治疗干预前，GDM患者的血清瘦素和血糖高于正常对照组（P＜0.05）；GDM治疗组在治疗后明显下降，分娩前血清瘦素和血糖与正常对照组水平相仿，但是GDM未治疗组血清瘦素和血糖高于其他两组（P＜0.05）；分娩后各组脐动脉血瘦素无明显差异，但是脐动脉血瘦素与婴儿出生体重具有显著相关性（P＜0.05）。GDM治疗组母婴并发症和产后糖尿病患病率低于GDM未治疗组（P＜0.05）。结论妊娠期糖尿病孕妇血清瘦素显著升高，瘦素水平能够在一定程度上反应母婴并发症以及罹患2型糖尿病的风险，建议临床监测GDM妇女血清瘦素水平，及时准确评估预后。
목적：관찰임신기당뇨병잉부적혈청수소수평，분석혈청수소여모영예후지간적관계。방법선취아원학진적42례GDM환자위연구대상，접수규범치료적30례위치료조，미치료적12례작위미치료조，수궤추취정상건강잉부32례위정상대조조，재잉24～28주、잉38～40주분면전、분면후（제동맥혈）분별검측혈청수소（ELISA법）화혈당，동시통계모영병발증、영인출생체중、산후모체2형당뇨병환병솔，병응용통계학연건대상관수거진행통계분석。결과재미진행치료간예전，GDM환자적혈청수소화혈당고우정상대조조（P＜0.05）；GDM치료조재치료후명현하강，분면전혈청수소화혈당여정상대조조수평상방，단시GDM미치료조혈청수소화혈당고우기타량조（P＜0.05）；분면후각조제동맥혈수소무명현차이，단시제동맥혈수소여영인출생체중구유현저상관성（P＜0.05）。GDM치료조모영병발증화산후당뇨병환병솔저우GDM미치료조（P＜0.05）。결론임신기당뇨병잉부혈청수소현저승고，수소수평능구재일정정도상반응모영병발증이급리환2형당뇨병적풍험，건의림상감측GDM부녀혈청수소수평，급시준학평고예후。
Objective To observe the serum leptin levels in patients with gestational diabetes mellitus and analyze the relationship between the levels and perinatal prognosis.Methods 42 GDM patients were selected as the research object, 30 cases with standard treatment (treatment group), the other 12 cases without treatment and 32 cases of normal healthy pregnant women were randomly selected as normal control group. Serum leptin and blood glucose (ELISA) were detected in 24 to 28 weeks and 38 to 40 weeks before and after delivery (Umbilical artery blood). The complications, infant birth weight and postpartum type 2 diabetes rate were analyzed. Results Before treatment, serum leptin and blood glucose in GDM patients were significantly higher than normal control group (P<0.05). It significant decreased after the treatment. But in untreated group, the levels were higher than the other two groups (P<0.05). The umbilical artery blood leptin was almost the same in each group, but there was significant ralationship between umbilical artery blood leptin and infant birth weight (P<0.05). The complications and prevalence of GDM in the treatment group were lower than that in the untreated group (P<0.05). Conclusion The maternal complications and the risk of type 2 diabetes mellitus in diabetic women, it is recommended to monitor serum leptin level in GDM, and to evaluate the prognosis of the disease.