CAJ | 학술논문

目的：探讨二甲双胍联合沙格列汀治疗2型糖尿病患者的临床疗效。方法选取2012年4月至2014年1月于中国医科大学附属第一医院鞍山医院就诊的2型糖尿病患者资料150例，按随机数字表法将患者分为观察组和对照组，各75例。对照组患者口服二甲双胍，观察组患者在对照组基础上口服沙格列汀。比较两组患者治疗前后空腹血糖（FPG）、餐后2 h血糖（2 hPBG）、体重指数（BMI）以及低血糖发生率。结果治疗后，观察组患者FPG、2 hPBG均明显低于对照组，差异均有统计学意义（均P＜0.05）；两组患者的BMI均明显低于治疗前，差异均有统计学意义（均P＜0.05）。结论二甲双胍联合沙格列汀可有效控制2型糖尿病患者血糖，安全有效，不会增加患者体重和低血糖发生率。
목적：탐토이갑쌍고연합사격렬정치료2형당뇨병환자적림상료효。방법선취2012년4월지2014년1월우중국의과대학부속제일의원안산의원취진적2형당뇨병환자자료150례，안수궤수자표법장환자분위관찰조화대조조，각75례。대조조환자구복이갑쌍고，관찰조환자재대조조기출상구복사격렬정。비교량조환자치료전후공복혈당（FPG）、찬후2 h혈당（2 hPBG）、체중지수（BMI）이급저혈당발생솔。결과치료후，관찰조환자FPG、2 hPBG균명현저우대조조，차이균유통계학의의（균P＜0.05）；량조환자적BMI균명현저우치료전，차이균유통계학의의（균P＜0.05）。결론이갑쌍고연합사격렬정가유효공제2형당뇨병환자혈당，안전유효，불회증가환자체중화저혈당발생솔。
Objective To investigate the clinical effect of metformin combined with Shah Glenn Dean in the treatment of type 2 diabetes melitus.Methods Selected 2012 January 4 to February 2014 in patients with type 2 diabetes melitus admitted in the First Affiliated Hospital of China Medical University Hospital of Anshan 150 cases,according to the random number table method,the patients were divided into observation group and control group,with 75 cases in each.Control group patients were treated with metformin,observation group of patients in the control group based on oral saxagliptin,compared two groups of patients before and after the fasting plasma glucose(FPG),postprandial 2 h blood glucose(2 hPBG)and body mass index(BMI)and the frequency of hypoglycemia incidence.Results After treatment and observation groups with FPG,2hPBG values were significantly lower than those in the control group,differences were statisticaly significant (P<0.05);the BMI of two groups of patients were significantly lower in the treatment before,differences were statisticaly significant(P<0.05).Conclusion Metformin combined with sand glibenclamide could effectively control the blood glucose in patients with type 2 diabetes melitus,safe and effective wil not increase in weight and hypoglycemia incidence.