CAJ | 학술논문

目的：探讨EGFR、VEGF和P-gp蛋白在老年人结直肠癌中的表达及其相关性分析。方法应用免疫组织化学技术对79例老年人结直肠癌病理切片进行EGFR、VEGF和P-gp的联合检测，并结合检测结果进行统计学分析。结果79例老年人结直肠腺癌组织中， VEGF、EGFR和P-gp蛋白的表达与结直肠腺癌组织的分化程度、浸润深度、是否有癌栓、淋巴结转移和Duck分期密切相关（P＜0.05）。EGFR表达与VEGF、P-gp阳性表达，及VEGF表达与P-gp阳性表达均无统计学意义（P＞0.05）。结论 VEGF、EGFR和P-gp的表达结果表明结直肠腺癌存在着多基因表达，这些基因可能参与了结直肠腺癌的发生和发展。三者的联合检测有助于判断结直肠腺癌的生物学行为和预后。
목적：탐토EGFR、VEGF화P-gp단백재노년인결직장암중적표체급기상관성분석。방법응용면역조직화학기술대79례노년인결직장암병리절편진행EGFR、VEGF화P-gp적연합검측，병결합검측결과진행통계학분석。결과79례노년인결직장선암조직중， VEGF、EGFR화P-gp단백적표체여결직장선암조직적분화정도、침윤심도、시부유암전、림파결전이화Duck분기밀절상관（P＜0.05）。EGFR표체여VEGF、P-gp양성표체，급VEGF표체여P-gp양성표체균무통계학의의（P＞0.05）。결론 VEGF、EGFR화P-gp적표체결과표명결직장선암존재착다기인표체，저사기인가능삼여료결직장선암적발생화발전。삼자적연합검측유조우판단결직장선암적생물학행위화예후。
Objective To explore EGFR ,VEGF and P-gp in colorectal carcinoma of elder people and their pathological relationship.Methods Immunohistochemical technique was used in VEGF, EGFR and P-gp joint detection for 79 cases of colorectal carcinoma biopsy. The result was statistically analyzed.Results Statistical analysis showed that VEGF, EGFR and P-gp protein expression was related to colorectal carcinoma tissue differentiation, depth of invasion, with or without tumor thrombus, lymph node metastasis, and Duck stage(P<0.05). EGFR expression wasn’t related to VEGF or P-gp expression, and VEGF expression wasn’t related to P-gp expression(P>0.05).Conclusions VEGF, EGFR and P-gp expression results in colorectal carcinoma show the existence of multi-gene expression, and these genes may be involved in the occurrence and development of colorectal carcinoma. The joint detection is helpful in determining the biological behavior and prognosis of colorectal carcinoma.