国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
International Medicine and Health Guidance News
2015年
20期
3051-3054
,共4页
难治性肾病综合征%普乐可复%疗效%血清相关炎性因子
難治性腎病綜閤徵%普樂可複%療效%血清相關炎性因子
난치성신병종합정%보악가복%료효%혈청상관염성인자
Refractory nephrotic syndrome%Tacrolimus capsules%Efficacy%Related serum inflammatory factors
目的 研究普乐可复治疗难治性肾病综合征的疗效及其对患儿血清相关炎性因子的影响.方法 将我院收治的难治性肾病综合征75例随机分为两组,两组均给予激素治疗,实验组38例在激素治疗基础上给予普乐可复治疗,对照组37例在激素治疗基础上给予环磷酰胺治疗,对比两组的临床疗效及对患儿血清相关炎性因子的影响.结果 实验组、对照组总有效率分别为94.71％、72.97％,实验组治疗后血清IL-2[(190.15±14.18) pg·ml-1]、sIL-2R[(183.14±17.84)U/ml]、甘油三脂[(1.98±0.64)U/L]、血浆白蛋白[(44.87±6.85) g/L]、24h尿蛋白[(0.75±0.14)mg]改善较对照组治疗后明显,两组比较差异有统计学意义(P＜0.05).结论 普乐可复治疗难治性肾病综合征,疗效显著,血清IL-2、sIL-2R、甘油三脂、血浆白蛋白、24 h尿蛋白改善明显,效果较为理想.
目的 研究普樂可複治療難治性腎病綜閤徵的療效及其對患兒血清相關炎性因子的影響.方法 將我院收治的難治性腎病綜閤徵75例隨機分為兩組,兩組均給予激素治療,實驗組38例在激素治療基礎上給予普樂可複治療,對照組37例在激素治療基礎上給予環燐酰胺治療,對比兩組的臨床療效及對患兒血清相關炎性因子的影響.結果 實驗組、對照組總有效率分彆為94.71％、72.97％,實驗組治療後血清IL-2[(190.15±14.18) pg·ml-1]、sIL-2R[(183.14±17.84)U/ml]、甘油三脂[(1.98±0.64)U/L]、血漿白蛋白[(44.87±6.85) g/L]、24h尿蛋白[(0.75±0.14)mg]改善較對照組治療後明顯,兩組比較差異有統計學意義(P＜0.05).結論 普樂可複治療難治性腎病綜閤徵,療效顯著,血清IL-2、sIL-2R、甘油三脂、血漿白蛋白、24 h尿蛋白改善明顯,效果較為理想.
목적 연구보악가복치료난치성신병종합정적료효급기대환인혈청상관염성인자적영향.방법 장아원수치적난치성신병종합정75례수궤분위량조,량조균급여격소치료,실험조38례재격소치료기출상급여보악가복치료,대조조37례재격소치료기출상급여배린선알치료,대비량조적림상료효급대환인혈청상관염성인자적영향.결과 실험조、대조조총유효솔분별위94.71％、72.97％,실험조치료후혈청IL-2[(190.15±14.18) pg·ml-1]、sIL-2R[(183.14±17.84)U/ml]、감유삼지[(1.98±0.64)U/L]、혈장백단백[(44.87±6.85) g/L]、24h뇨단백[(0.75±0.14)mg]개선교대조조치료후명현,량조비교차이유통계학의의(P＜0.05).결론 보악가복치료난치성신병종합정,료효현저,혈청IL-2、sIL-2R、감유삼지、혈장백단백、24 h뇨단백개선명현,효과교위이상.
Objective To study the efficacy of Tacrolimus capsules in the treatment of children with refractory nephrotic syndrome and its effect on related serum inflammatory factors.Methods 75 cases of refractory nephrotic syndrome in our hospital were randomly divided into two groups.Two groups were treated with hormone therapy, 38 cases in experimental group received Tacrolimus capsules, 37 cases in control group received cyclophosphamide.Compared the clinical efficacy of two groups and related serum inflammatory factors.Results The total effective rate in experimental group and control group were 94.71％, 72.97％ respectively.After treatment, serum IL-2 [(190.15±14.18)pg/ml], sIL-2R [(183.14±17.84) U/ml], triglycerides [(1.98±0.64)U/L], serum albumin [(44.87±6.85)g/L], 24 h urine protein [(0.75±0.14) mg] in experimental group improved more significantly that those in control group (P＜0.05).Conclusion Tacrolimus capsules in the treatment of children with refractory nephrotic syndrome has a significant effect, with serum IL-2, sIL-2R, triglycerides, serum albumin, 24 h urine protein improving significantly.
