CAJ | 학술논문

文章概述了从海胆壳棘中发现的一些具代表性、结构独特、有生物活性的天然产物：萘醌类色素、苯醌类色素、类胡萝卜素、具有离子通道调控与抗肿瘤及免疫调节活性的蛋白质等，就相应分离纯化手段、合成路线、生物活性与潜在药用价值作简要概述，并简述了基因测序与生物信息学分析在海胆壳棘功能活性蛋白研究上的应用以及传统中药实践中海胆壳棘的功效等内容。
문장개술료종해담각극중발현적일사구대표성、결구독특、유생물활성적천연산물：내곤류색소、분곤류색소、류호라복소、구유리자통도조공여항종류급면역조절활성적단백질등，취상응분리순화수단、합성로선、생물활성여잠재약용개치작간요개술，병간술료기인측서여생물신식학분석재해담각극공능활성단백연구상적응용이급전통중약실천중해담각극적공효등내용。
Marine natural products vary from small molecules to high molecular weight proteins and display u-nique chemical and biological features of scientific interest. Many of these substances can serve as useful re-search tools or molecular models for the design of new drugs. This review summarizes the current knowledge of the following biologically active components isolated and characterized from the test, spines and pedicellaria of sea urchin: naphthoquinone pigments, benzoquinone pigment, carotenoid, ion channel-targeted proteins, anticancer and immunologically active proteins. Other topics covered include the use of bioinformatics analysis in investigating protein profiling and the application of sea urchin test and spines in traditional Chinese medi-cine.