CAJ | 학술논문

目的：探讨伴轻度认知障碍（mild cognitive impairment, MCI）的正常眼压性青光眼（normal tension glaucoma , NTG）患者多导睡眠图的特点。方法本研究对35例经北京大学第三医院眼科确诊为NTG的患者，均进行神经心理量表测评、匹兹堡睡眠质量指数（Pittsburgh slrrp quality index, PSQI）和多导睡眠图（poly?somnography, PSG）检查，其中伴MCI者16例（伴MCI组），不伴MCI者19例（不伴MCI组）。结果 PSQI显示伴MCI组中有睡眠障碍者占43.8%（7/16例），其PSQI总分高于不伴MCI组，差异有统计学意义（P<0.05）。不伴MCI组患者睡眠效率正常，且优于伴MCI组，差异有统计学意义（P<0.05）。PSG显示伴MCI组患者87.5%（14/16）存在PSG睡眠结构紊乱。伴MCI组较不伴MCI组NREM期N3期睡眠时间明显缩短，差异有统计学意义（P<0.05）。结论伴MCI组NTG患者更易出现睡眠障碍，睡眠结构紊乱、尤其是NREM期N3期睡眠时间的缩短与NTG患者认知功能下降有关。
목적：탐토반경도인지장애（mild cognitive impairment, MCI）적정상안압성청광안（normal tension glaucoma , NTG）환자다도수면도적특점。방법본연구대35례경북경대학제삼의원안과학진위NTG적환자，균진행신경심리량표측평、필자보수면질량지수（Pittsburgh slrrp quality index, PSQI）화다도수면도（poly?somnography, PSG）검사，기중반MCI자16례（반MCI조），불반MCI자19례（불반MCI조）。결과 PSQI현시반MCI조중유수면장애자점43.8%（7/16례），기PSQI총분고우불반MCI조，차이유통계학의의（P<0.05）。불반MCI조환자수면효솔정상，차우우반MCI조，차이유통계학의의（P<0.05）。PSG현시반MCI조환자87.5%（14/16）존재PSG수면결구문란。반MCI조교불반MCI조NREM기N3기수면시간명현축단，차이유통계학의의（P<0.05）。결론반MCI조NTG환자경역출현수면장애，수면결구문란、우기시NREM기N3기수면시간적축단여NTG환자인지공능하강유관。
Objective To assess the characteristic of normal tension glaucoma (NTG) patients with mild cogni?tive impairment (MCI). Methods This study included twenty-six cases of normal tension glaucoma patients who were diagnosed at ophthalmology department of Peking University Third Hospital. All the participants were examined by us?ing the scales of Montreal Cognitive Assessment (MoCA), mini-mental state examination(MMSE), clinical dementia rat?ing (CDR), activities of daily living (ADL), Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD), Pitts?burgh Sleep Quality Index (PSQI) and polysomnography (PSG). The patients were then divided into Group with MCI (16 cases) and Group without MCI (19 cases). Results There was no difference between the two groups in gender, age, edu?cation, depression, anxiety and body mass index (BMI) (P>0.05), but significant difference in MoCA scores (P<0.05). The incidence rate of sleep disorder of PSQI in was 28.6%(10/35 patients) of total NTG patients, 43.8%(7/16 patients) in Group with MCI, and 15.8% (3/19 patients) in Group without MCI, respectively. The PSQI score was higher in Group with MCI than in Group without MCI (P<0.05). Sleep efficiency was higher in Group without MCI than in Group with MCI (P<0.05), but no difference was found between the two groups in six other indexes of PSQI (P>0.05). The in?cidence rate of sleep structure disorder of PSG in all the NTG patients was 85.7%(30/35 patients), 87.5%(14/16 pa?tients) in Group with MCI, and 84.2%(16/19 patients) in Group without MCI. Sleep time of NREM-N3 was significant?ly shorter in Group with MCI than in Group without MCI (P<0.05), but no difference was found between those groups in total sleep time, sleep efficiency, sleep latency and REM time (P>0.05). Conclusion NTG patients with mild cogni?tive impairment are more prone to sleep disorders, especially sleep structure disturbance and short NREM-N3 time may affect cognitive function.