中国神经精神疾病杂志
中國神經精神疾病雜誌
중국신경정신질병잡지
Chinese Journal of Nervous and Mental Diseases
2015年
9期
518-522
,共5页
陈大春%张荣珍%陈科%修梅红%郭逸成%杨甫德%张向阳
陳大春%張榮珍%陳科%脩梅紅%郭逸成%楊甫德%張嚮暘
진대춘%장영진%진과%수매홍%곽일성%양보덕%장향양
精神分裂症%抗氧化剂%自由基
精神分裂癥%抗氧化劑%自由基
정신분렬증%항양화제%자유기
First-episode schizophrenia%Antioxidant%Free radicals
目的：探讨利培酮对非酶抗氧化物浓度的影响。方法纳入首发精神分裂症患者161例，接受10周单一利培酮治疗，138例患者完成研究。另设与患者年龄、性别、受教育程度相匹配的正常对照42名。采用阳性和阴性症状量表（positive and negative syndrome scale，PANSS）评估患者精神症状；治疗前后检测患者血清白蛋白、胆红素、尿酸浓度，对照组仅检测一次。结果治疗前患者组白蛋白、尿酸浓度低于对照组，患者组直接胆红素浓度高于对照组，间接胆红素浓度低于对照组（均P<0.05)。与治疗前比较，治疗后患者尿酸、总胆红素、直接胆红素、间接胆红素浓度下降（均P<0.05），且PANSS总分降低（P<0.05)。多因素线性回归分析显示，患者PANSS总分改善值与治疗前尿酸浓度相关联（β=0.27，P<0.01）。结论利培酮可引起首发精神分裂症患者非酶抗氧化物浓度下降，某些抗氧化物浓度可能与临床疗效存在关联。
目的：探討利培酮對非酶抗氧化物濃度的影響。方法納入首髮精神分裂癥患者161例，接受10週單一利培酮治療，138例患者完成研究。另設與患者年齡、性彆、受教育程度相匹配的正常對照42名。採用暘性和陰性癥狀量錶（positive and negative syndrome scale，PANSS）評估患者精神癥狀；治療前後檢測患者血清白蛋白、膽紅素、尿痠濃度，對照組僅檢測一次。結果治療前患者組白蛋白、尿痠濃度低于對照組，患者組直接膽紅素濃度高于對照組，間接膽紅素濃度低于對照組（均P<0.05)。與治療前比較，治療後患者尿痠、總膽紅素、直接膽紅素、間接膽紅素濃度下降（均P<0.05），且PANSS總分降低（P<0.05)。多因素線性迴歸分析顯示，患者PANSS總分改善值與治療前尿痠濃度相關聯（β=0.27，P<0.01）。結論利培酮可引起首髮精神分裂癥患者非酶抗氧化物濃度下降，某些抗氧化物濃度可能與臨床療效存在關聯。
목적：탐토리배동대비매항양화물농도적영향。방법납입수발정신분렬증환자161례，접수10주단일리배동치료，138례환자완성연구。령설여환자년령、성별、수교육정도상필배적정상대조42명。채용양성화음성증상량표（positive and negative syndrome scale，PANSS）평고환자정신증상；치료전후검측환자혈청백단백、담홍소、뇨산농도，대조조부검측일차。결과치료전환자조백단백、뇨산농도저우대조조，환자조직접담홍소농도고우대조조，간접담홍소농도저우대조조（균P<0.05)。여치료전비교，치료후환자뇨산、총담홍소、직접담홍소、간접담홍소농도하강（균P<0.05），차PANSS총분강저（P<0.05)。다인소선성회귀분석현시，환자PANSS총분개선치여치료전뇨산농도상관련（β=0.27，P<0.01）。결론리배동가인기수발정신분렬증환자비매항양화물농도하강，모사항양화물농도가능여림상료효존재관련。
Objective To explore the effect of resperidone treatment on serum levels of nonenzymatic antioxidant in drug-na?ve first-episode schizophrenic patients. Methods One hundred and sixty one schizophrenic patients and for?ty two normal controls matched for sex and education were recruited. The patients were treated with risperidone. Positive and negative syndrome scale (PANSS) were used to estimate the clinical effects. Serum albumin, bilirubin and uric acid levels were detected in the patients before and after 10-week treatment with risperidone and in normal controls. One hun?dred and thirty eight patients with schizophrenia had finished the study. Results Albumin and once uric acid levels were significantly lower in patients compared to the controls (all P<0.05). Direct bilirubin levels was higher in patients than in the controls (P<0.05). Indirect bilirubin level in patients was lower comparing to the normal controls (P<0.05). Uric acid, total bilirubin, direct and indirect bilirubin levels were significantly decreased after treatment (all P<0.05). The reduction in the PANSS total score from baseline to week 10 were associated with uric acid at baseline (β=0.27, P<0.01). Conclu?sions Reperidone may decrease nonenzymatic antioxidant levels in first-episode schizophrenic patients. Some antioxi?dant levels at pre-treatment may be associated with improvement of psychopathological symptoms.
