CAJ | 학술논문

目的：探讨抑郁障碍和双相障碍患者局部脑血流量（regional cerebral blood flow，r-CBF）特点及差异。方法纳入未经治疗的发作期抑郁障碍（major depression disorder，MDD）、双相障碍抑郁发作（bipolar disor?der，BPD）患者各22例及15名健康对照，采用单光子发射型计算机断层扫描（single-photon emission computed to?mography，SPECT）进行局部脑血流灌注显像，并比较各组的局部血流灌注情况。结果与对照组相比，MDD、BPD患者均存在双侧颞叶、顶叶、基底节血流灌注降低（P<0.001），MDD患者基底节灌注低于BPD患者（P<0.001）。结论 MDD、BPD患者均存在静息状态脑血流灌注下降，基底节灌注不同是BPD与MDD患者脑血流灌注特征的主要差异。该差异或许可视为鉴别MDD与BPD的生物学标记。
목적：탐토억욱장애화쌍상장애환자국부뇌혈류량（regional cerebral blood flow，r-CBF）특점급차이。방법납입미경치료적발작기억욱장애（major depression disorder，MDD）、쌍상장애억욱발작（bipolar disor?der，BPD）환자각22례급15명건강대조，채용단광자발사형계산궤단층소묘（single-photon emission computed to?mography，SPECT）진행국부뇌혈류관주현상，병비교각조적국부혈류관주정황。결과여대조조상비，MDD、BPD환자균존재쌍측섭협、정협、기저절혈류관주강저（P<0.001），MDD환자기저절관주저우BPD환자（P<0.001）。결론 MDD、BPD환자균존재정식상태뇌혈류관주하강，기저절관주불동시BPD여MDD환자뇌혈류관주특정적주요차이。해차이혹허가시위감별MDD여BPD적생물학표기。
Objective To investigate the characteristic of regional cerebral blood flow (r-CBF) in patients with major depression disorder (MDD) and bipolar depressed (BPD). Methods The r-CBF imaging was detected by using sin?gle emission computed tomography (SPECT) in 22 treatment naive patients with MDD, 22 treatment naive patients with BPD and 15 healthy controls. The r-CBF was compared between patients and controls. Results Compared to controls, the r-CBF in the bilateral temporal lobe, parietal lobe and basal ganglia significantly decreased in MDD and BPD pa?tients (P<0.001). The r-CBF in the basal ganglia was significantly lower in MDD patients than in BPD patients. Conclu?sion The r-CBF is abnormal in MDD and BPD at the resting state. The r-CBF in the basal ganglia is the main differ?ence between MDD and BPD. The difference might be regarded as a biomarker in distinguishing BPD patients from MDD patients.