CAJ | 학술논문

人类乳头瘤病毒(HPV)持续感染是导致宫颈癌发生的主要原因,但是越来越多的证据表明单独HPV感染不足以导致宫颈的恶性转化,其他基因表达水平的改变也参与了宫颈癌的发生和发展.近期研究发现,多种miRNA参与宫颈癌的病理进程,其中在宫颈癌中高表达的miR-21可以通过阻遏肿瘤抑制相关基因,如PTEN、PDCD4、TPM1、CCL20 和LATS1等的表达而发挥癌基因的作用.本文就miR-21与宫颈癌的关系的研究进展做一综述.
인류유두류병독(HPV)지속감염시도치궁경암발생적주요원인,단시월래월다적증거표명단독HPV감염불족이도치궁경적악성전화,기타기인표체수평적개변야삼여료궁경암적발생화발전.근기연구발현,다충miRNA삼여궁경암적병리진정,기중재궁경암중고표체적miR-21가이통과조알종류억제상관기인,여PTEN、PDCD4、TPM1、CCL20 화LATS1등적표체이발휘암기인적작용.본문취miR-21여궁경암적관계적연구진전주일종술.
Persistent infection of high risk HPV (human papilloma virus) is a major cause of cervical cancer. However, growing evidence indicate that HPV infection alone is not enough to cause the malignant transformation of cervical cells. Change of the expression levels in other genes is also involved in the occurrence and development of cervical cancer. Recent studies found that many miRNAs were involved in the pathological process of cervical cancer. Among these miRNAs, the high-expressed miR-21 in cervical cancer plays the role of oncogene by inhibiting the ex-pression of multiple tumor suppressor genes such as PTEN, PDCD4, TPM1, CCL20 and LATS1. The article here makes a brief review on the research progress on the relationship between miR-21 and cervical cancer.