CAJ | 학술논문

目的通过检测146例喘息患儿FcεRI-β基因多态性与临床表现、药物疗效相关性的研究,探讨该基因多态性对喘息患儿的易感性与疗效的作用.方法选取住院喘息患儿146例,用荧光定量PCR法检测患儿FcεRI-β基因,其中AG、GG为风险基因型,共41例,AA为正常基因型,共105例;记录两组患儿的喘息发作程度、检测肺功能;记录两组临床疗效(雾化治疗、全身使用糖皮质激素、住院时间、后续治疗).结果风险型基因组与正常型基因组在喘息发作严重程度中的分布差异有统计学意义,P=0.003,风险型基因组较正常型基因组喘息发作严重;两组患儿在肺功能异常上差异无统计学意义,P=0.53;两组在雾化治疗上差异无统计学意义,P=0.74;两组在使用全身糖皮质激素上差异无统计学意义,P=0.21;两组在住院时间上差异无统计学意义,P=0.21;两组患儿在后续治疗上差异无统计学意义,P=0.63.结论 FcεRI-β基因多态性与患儿的喘息发病相关,风险型基因是喘息发生的危险因素;风险型基因影响喘息发作的严重程度;但不是影响肺功能的主要因素;基因多态性不是影响疗效的主要因素.
목적 통과검측146례천식환인FcεRI-β기인다태성여림상표현、약물료효상관성적연구,탐토해기인다태성대천식환인적역감성여료효적작용.방법 선취주원천식환인146례,용형광정량PCR법검측환인FcεRI-β기인,기중AG、GG위풍험기인형,공41례,AA위정상기인형,공105례;기록량조환인적천식발작정도、검측폐공능;기록량조림상료효(무화치료、전신사용당피질격소、주원시간、후속치료).결과 풍험형기인조여정상형기인조재천식발작엄중정도중적분포차이유통계학의의,P=0.003,풍험형기인조교정상형기인조천식발작엄중;량조환인재폐공능이상상차이무통계학의의,P=0.53;량조재무화치료상차이무통계학의의,P=0.74;량조재사용전신당피질격소상차이무통계학의의,P=0.21;량조재주원시간상차이무통계학의의,P=0.21;량조환인재후속치료상차이무통계학의의,P=0.63.결론 FcεRI-β기인다태성여환인적천식발병상관,풍험형기인시천식발생적위험인소;풍험형기인영향천식발작적엄중정도;단불시영향폐공능적주요인소;기인다태성불시영향료효적주요인소.
Objective To investigate the correlation between FcεRI-βgene polymorphisms and the clinical manifestations and curative effect in wheezing infants.Methods 146 wheezing infants were recruited and divided into a risk genotype group (n=41) and a normal genotype group(n=105).FcεRI-β was detected with PCR.The genotype distribution, clinical manifestations, lung function, and curative effect were analyzed and compared between the two groups.Results FcεR1-β E237G AG/GG was more serious than FcεR1 AA in wheezing infants (x 2=14.202, P=0.003).There were no statistical differences in lung function, curative effect, glucocorticoid use,hospital stay, and subsequent treatment between these two groups (P>0.05).Conclusions FcεRI-βgene polymorphisms correlates with infantile wheezing.Risk genotype infects wheezing seriousness but isn't the main factor affecting lung function.FcεRI-βgene polymorphisms isn't the main factor affecting curative effect.