CAJ | 학술논문

采用化学共沉法制备 Fe3 O 4磁性微粒，用水溶性较好的羧化壳聚糖及用于治疗基底细胞瘤、光化性骨化病的氨基酮戊酸对 Fe3 O 4磁性微粒进行两层包覆，最终形成载药 Fe3 O 4/羧化壳聚糖磁性液体。采用 XRD、TEM 和 FT-IR 对载药纳米 Fe3 O 4/羧化壳聚糖磁性液体复合微球的晶型结构、官能团组成及微粒尺寸和形貌等进行了表征。检测结果说明，制备的载药纳米 Fe3 O 4/羧化壳聚糖磁性液体，其核心组份为晶型较好的 Fe3 O 4磁性纳米微粒，磁性微粒的粒径范围为9~11 nm；载药 Fe3 O 4/羧化壳聚糖磁性复合微球成类球状；氨基酮戊酸、羧化壳聚糖和 Fe3 O 4分子间发生了化学键的作用；在外加磁场作用下，观察到载药磁性液体的定向移动，有望实现在肿瘤治疗上的主动靶向给药作用。
채용화학공침법제비 Fe3 O 4자성미립，용수용성교호적최화각취당급용우치료기저세포류、광화성골화병적안기동무산대 Fe3 O 4자성미립진행량층포복，최종형성재약 Fe3 O 4/최화각취당자성액체。채용 XRD、TEM 화 FT-IR 대재약납미 Fe3 O 4/최화각취당자성액체복합미구적정형결구、관능단조성급미립척촌화형모등진행료표정。검측결과설명，제비적재약납미 Fe3 O 4/최화각취당자성액체，기핵심조빈위정형교호적 Fe3 O 4자성납미미립，자성미립적립경범위위9~11 nm；재약 Fe3 O 4/최화각취당자성복합미구성류구상；안기동무산、최화각취당화 Fe3 O 4분자간발생료화학건적작용；재외가자장작용하，관찰도재약자성액체적정향이동，유망실현재종류치료상적주동파향급약작용。
Preparation of Fe3 O 4 magnetic particle loading drug by chemical co-precipitation,with carboxylation chitosan and 5-aminolevulinic acid which was mainly used for treatment of basal cell carcinoma and actinic ossifi-cation disease for two layer coated Fe3 O 4 magnetic liquid.The product was by XRD,TEM and FT-IR.Results show that magnetic particles was crystal type of Fe3 O 4 magnetic liquid;Fe3 O 4/carboxyl chitosan composite par-ticle loading 5-aminolevulinic acid was about 1 1 nm in size;the Fe3 O 4/carboxyl chitosan composite particle loading 5-aminolevulinic acid was near-spherical;carboxyl chitosan,5-aminolevulinic acid and Fe3 O 4 molecular presence chemical adsorption;Fe3 O 4/carboxyl chitosan composite particle loading 5-aminolevulinic acid move direction in extra magnetic field,contribute to target administration in cancer therapy.