CAJ | 학술논문

目的：探讨胎盘多肽注射液对股骨粗隆间骨折（IFF）愈合程度的改善作用。方法：选取IFF手术患者113例，采用随机数字表法将患者分为对照组（n=56，术后采用常规抗感染药物治疗）和观察组（n=57，在对照组基础上采用胎盘多肽注射液治疗），采用ELISA方法测定血清血小板衍生生长因子（PDGF）和人胰岛素生长因子-1（IGF-1）水平，比较两组骨折愈合时间、住院时间、术后感染、髋关节功能Harris评分和血清PDGF、IGF-1水平的差异。结果：观察组骨折愈合时间和住院时间及术后感染率均明显低于对照组（P＜0.05）；治疗前，两组Harris评分和血清PDGF、IGF-1水平比较差异无统计学意义（P＞0.05），治疗后，全部患者上述指标均明显高于治疗前（P＜0.05），其中观察组上述指标明显高于对照组（P＜0.05）。结论：胎盘多肽注射液可能通过增加血清PDGF、IGF-1水平显著改善IFF愈合程度，降低骨折愈合时间和住院时间，改善髋关节功能和降低术后感染风险。
목적：탐토태반다태주사액대고골조륭간골절（IFF）유합정도적개선작용。방법：선취IFF수술환자113례，채용수궤수자표법장환자분위대조조（n=56，술후채용상규항감염약물치료）화관찰조（n=57，재대조조기출상채용태반다태주사액치료），채용ELISA방법측정혈청혈소판연생생장인자（PDGF）화인이도소생장인자-1（IGF-1）수평，비교량조골절유합시간、주원시간、술후감염、관관절공능Harris평분화혈청PDGF、IGF-1수평적차이。결과：관찰조골절유합시간화주원시간급술후감염솔균명현저우대조조（P＜0.05）；치료전，량조Harris평분화혈청PDGF、IGF-1수평비교차이무통계학의의（P＞0.05），치료후，전부환자상술지표균명현고우치료전（P＜0.05），기중관찰조상술지표명현고우대조조（P＜0.05）。결론：태반다태주사액가능통과증가혈청PDGF、IGF-1수평현저개선IFF유합정도，강저골절유합시간화주원시간，개선관관절공능화강저술후감염풍험。
Objective:To investigate the effect of placental polypeptide injection on healing degree of intertrochanter fracture of femur (IFF).Methods:One hundred and thirteen cases of patients received IFF operation were randomly divided into a control group (n=56, given postoperative conventional anti-infection therapy) and an observation group (n=57, given placenta polypeptide injection on the base of control group). The levels of serum platelet derived growth factor (PDGF) and insulin-like growth factor-1 (IGF-1) were detected by an ELISA method. The times for fracture healing and hospitalization, postoperative infection, Harris hip score and the levels of serum PDGF and IGF-1 were compared between two groups.Results:The times for fracture healing and hospitalization and the infection rate of postoperation were signiifcantly lower in the observation group than in the control group (P<0.05). There was no statistical signiifcance in Harris score, serum PDGF and IGF-1 levels between two groups before treatment (P>0.05). The indicators above mentioned were signiifcantly higher after treatment than before (P<0.05) and in the observation group than in the control group (P<0.05).Conclusion:Placenta polypeptide injection can improve femoral intertrochanteric fracture healing degree and the function of hip joint and reduce the times for fracture healing and hospitalization and infection risk by signiifcantly increasing the levels of serum PDGF and IGF-1.