CAJ | 학술논문

目的：调查中国大陆汉族慢性丙型肝炎（ CHC ）患者的HCV基因型与地区分布、性别、HCV－RNA复制水平之间的关系。方法：选取来自中国大陆不同地区28家医院的1014例汉族CHC 患者，对其性别、分布区域、HCV 基因型、HCV－RNA复制水平等指标进行调查，用SPSS 20．0软件进行数据处理，采用χ2检验分析各指标的相互关系。结果：①中国大陆HCV 1型患者人数最多（56．80％）；除西南、华南、华中地区外，其余地区HCV基因型分布频度均为HCV 1型＞HCV 2型＞HCV 3型＞HCV 6型。②HCV 1型在华南地区男性患者多见（ P＜0．05）；HCV 2型在华北地区女性多见（ P＜0．05）；HCV 3型在华北、西北地区男性多见（ P＜0．05）；HCV 6型在西北地区男性多见（ P＜0．05），其余各地区不同性别间HCV基因型分布差异无统计学意义。③在HCV 1、HCV 2、HCV 3、HCV 6型中，均多见HCV－RNA高水平复制，低水平复制患者数最少。结论：中国大陆汉族CHC患者HCV基因型在各地区分布不同，并与性别、HCV－RNA复制水平有关。
목적：조사중국대륙한족만성병형간염（ CHC ）환자적HCV기인형여지구분포、성별、HCV－RNA복제수평지간적관계。방법：선취래자중국대륙불동지구28가의원적1014례한족CHC 환자，대기성별、분포구역、HCV 기인형、HCV－RNA복제수평등지표진행조사，용SPSS 20．0연건진행수거처리，채용χ2검험분석각지표적상호관계。결과：①중국대륙HCV 1형환자인수최다（56．80％）；제서남、화남、화중지구외，기여지구HCV기인형분포빈도균위HCV 1형＞HCV 2형＞HCV 3형＞HCV 6형。②HCV 1형재화남지구남성환자다견（ P＜0．05）；HCV 2형재화북지구녀성다견（ P＜0．05）；HCV 3형재화북、서북지구남성다견（ P＜0．05）；HCV 6형재서북지구남성다견（ P＜0．05），기여각지구불동성별간HCV기인형분포차이무통계학의의。③재HCV 1、HCV 2、HCV 3、HCV 6형중，균다견HCV－RNA고수평복제，저수평복제환자수최소。결론：중국대륙한족CHC환자HCV기인형재각지구분포불동，병여성별、HCV－RNA복제수평유관。
Objective: To investigate the distribution of HCV genotypes in Chinese Han population with chronic hepatitis C ( CHC ) . Methods: This randomized multicenter study included 1 014 CHC patients from 28 hospitals in different regions of China.SPSS 20.0 was applied to analyze the relationship among region, HCV genotype, gender and the replication level of HCV-RNA.Results: HCV 1 genotype (56.80%) was the most common genotype.The majority of CHC patients were of genotype 1, 2, 3, 6 in the order of frequency, except those in southwestern, southern and central China.HCV 1, 2, 3, 6 genotypes were most common among male patients in southern China; among female patients in northern China; among male patients in northern and northwestern China and among male patients in northwestern China, respectively ( all P <0 .05 ) .There was no statistical significance between different genders in other regions.The high viral load was more common than the low viral load among HCV 1, 2, 3, 6 genotype-infected patients.Conclusion: There are different distributions of HCV genotypes among the different regions. In addition, HCV genotypes are correlated with gender and HCV-RNA load.