CAJ | 학술논문

酒精性痴呆日益成为严峻的医学和社会问题，整体机制不明是目前酒精性脑损伤干预和治疗的瓶颈。突触作为神经元之间递质释放与跨膜信息传递及整合的核心结构，对于学习记忆等脑的高级功能具有决定性作用。本文基于突触传递的神经生物学基础，围绕酒精分子胁迫下突触传递过程和效率的变化，分别从突触形态结构、物质基础、信号转导等层面，系统评述了酒精性脑损伤的突触机制及其修复策略，以期为酒精性脑损伤的深入研究和益智类保健食品开发提供思路借鉴。
주정성치태일익성위엄준적의학화사회문제，정체궤제불명시목전주정성뇌손상간예화치료적병경。돌촉작위신경원지간체질석방여과막신식전체급정합적핵심결구，대우학습기억등뇌적고급공능구유결정성작용。본문기우돌촉전체적신경생물학기출，위요주정분자협박하돌촉전체과정화효솔적변화，분별종돌촉형태결구、물질기출、신호전도등층면，계통평술료주정성뇌손상적돌촉궤제급기수복책략，이기위주정성뇌손상적심입연구화익지류보건식품개발제공사로차감。
Alcoholic dementia is increasingly becoming both a severe medical issue and a social problem;the unknown overall mecha-nism is the bottleneck for effective intervention and treatment of alcoholic brain injury. As the primary structure for the release, transmission of neurotransmitter and information integration between neurons, synapse plays a significant role in performing the advanced function of brain, such as learning and memory. Based on the neurobiological principles of synaptic structure and function, the changes in process and efficiency of synaptic transmission and information integration stressed by alcoholic molecular were reviewed in comparison with the nor-mal process. The molecular mechanisms for alcoholic brain damage in learning and memory abilities were systematically discussed from the levels of synaptic morphology, material components, and signal transduction, respectively, and the repairing strategies for the damaged syn-aptic structure were proposed accordingly. Hopefully, this review could provide a deep insight into understanding the molecular mechanism of alcoholic brain damage, and draw ideas for the memory-enhancing peptides development.