CAJ | 학술논문

目的：观察大黄对戊四唑（pentylenetetrazol，PTZ）癫痫大鼠的脑保护作用。方法采用戊四唑复制癫痫大鼠模型，给予大黄4、2、1 g / kg，灌胃1次/ d。观察大鼠的惊厥发作频率、发作潜伏时间及行为变化。测定脑组织超氧化物歧化酶（superoxide，SOD）、丙二醛（malondialdehyde，MDA）、谷光甘肽过氧化物酶（glutathione peroxidase，GSH-PX）活性。结果大黄可延长戊四唑癫痫大鼠发作潜伏期，大约1 min，缩短持续时间2 min 左右。提高脑组织 SOD 含量10 U/ mg、GSH-PX 活性10 U/ mg，降低 MDA 水平1 nmol/ mg。结论大黄可以对抗戊四唑大鼠癫痫发作及脑组织氧化，对癫痫有一定的防治作用。
목적：관찰대황대무사서（pentylenetetrazol，PTZ）전간대서적뇌보호작용。방법채용무사서복제전간대서모형，급여대황4、2、1 g / kg，관위1차/ d。관찰대서적량궐발작빈솔、발작잠복시간급행위변화。측정뇌조직초양화물기화매（superoxide，SOD）、병이철（malondialdehyde，MDA）、곡광감태과양화물매（glutathione peroxidase，GSH-PX）활성。결과대황가연장무사서전간대서발작잠복기，대약1 min，축단지속시간2 min 좌우。제고뇌조직 SOD 함량10 U/ mg、GSH-PX 활성10 U/ mg，강저 MDA 수평1 nmol/ mg。결론대황가이대항무사서대서전간발작급뇌조직양화，대전간유일정적방치작용。
Objective To explore the protective effects on brain of rhubarb after epilepsy by pentylenetetrazol. Meth-ods A epilepsy model on rats was establ-ished by injecting pentylenetetrazol,the rats were respectively treated with rhubarb 4 g / kg,2 g / kg and 1 g / kg,one time a day. Observing the frequency of convulsions attacking on rats,the incu-bation time and behavioral changes. The brain tissue superoxide(SOD),malondialdehyde( MDA)and glutathione peroxidase(GSH-Px)activity were measured. Results Rhubarb could extend the incubation period of rats abou 1 minute after Epilepsy by pentylenetetrazol,reduce the duration of about 2 minutes,increase the activity of SOD of 10 U/ mg,GSH-Px of 10 U/ mg and decrease MDA content of 1 nmol/ mg. Conclusion Rhubarb could fight epilepsy by pentylenetetrazol in rats and oxidation of brain tissue. It is proved that rhubarb can obviously prevent and cure epilepsy.