临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
Journal of Clinical and Experimental Medicine
2015年
21期
1830-1833
,共4页
细菌性血流感染%PCT%CRP%NEU％%联合检测
細菌性血流感染%PCT%CRP%NEU％%聯閤檢測
세균성혈류감염%PCT%CRP%NEU％%연합검측
Bacterial bloodstream infection%Serum PCT%CRP%NEU％%Joint detection
目的：探讨联合检测血清降钙素原（PCT）、C 反应蛋白（CRP）及中性粒细胞百分比（NEU%）对早期预测细菌性血流感染的诊断价值。方法随机选择376例住院患者进行研究，均为入院后首次送检血培养并同时检测 PCT、CRP 及 NEU%。结果血培养阳性组103例，阴性组273例。较之阴性组，阳性组的 PCT、CRP 及 NEU%水平均出现明显上升的情况，经比较差异均有统计学意义（均 P ﹤0.05）。绘制 PCT、CRP 及 NEU%诊断细菌性血流感染的 ROC 曲线，三者对细菌性血流感染均具有一定的诊断价值（均 P ﹤0.05）。对三者的 ROC 曲线下面积进行两两 Z 检验比较，可得 PCT 均显著大于 CRP 和 NEU%（均 P ﹤0.05），且 CRP 与 NEU%比较差异无统计学意义（ P ﹥0.05）。联合检测与单项诊断能力较高 PCT 比较灵敏度出现下降，但差异无统计学意义（ P ﹥0.05）；特异度上升，且差异有统计学意义（ P ﹤0.05）。作为排除标准，三项指标均为阴性时，阴性预测值和特异度均达到100.0%。结论联合检测血清 PCT、CRP 及NEU%对早期预测细菌性血流感染具有一定的的诊断价值。
目的：探討聯閤檢測血清降鈣素原（PCT）、C 反應蛋白（CRP）及中性粒細胞百分比（NEU%）對早期預測細菌性血流感染的診斷價值。方法隨機選擇376例住院患者進行研究，均為入院後首次送檢血培養併同時檢測 PCT、CRP 及 NEU%。結果血培養暘性組103例，陰性組273例。較之陰性組，暘性組的 PCT、CRP 及 NEU%水平均齣現明顯上升的情況，經比較差異均有統計學意義（均 P ﹤0.05）。繪製 PCT、CRP 及 NEU%診斷細菌性血流感染的 ROC 麯線，三者對細菌性血流感染均具有一定的診斷價值（均 P ﹤0.05）。對三者的 ROC 麯線下麵積進行兩兩 Z 檢驗比較，可得 PCT 均顯著大于 CRP 和 NEU%（均 P ﹤0.05），且 CRP 與 NEU%比較差異無統計學意義（ P ﹥0.05）。聯閤檢測與單項診斷能力較高 PCT 比較靈敏度齣現下降，但差異無統計學意義（ P ﹥0.05）；特異度上升，且差異有統計學意義（ P ﹤0.05）。作為排除標準，三項指標均為陰性時，陰性預測值和特異度均達到100.0%。結論聯閤檢測血清 PCT、CRP 及NEU%對早期預測細菌性血流感染具有一定的的診斷價值。
목적：탐토연합검측혈청강개소원（PCT）、C 반응단백（CRP）급중성립세포백분비（NEU%）대조기예측세균성혈류감염적진단개치。방법수궤선택376례주원환자진행연구，균위입원후수차송검혈배양병동시검측 PCT、CRP 급 NEU%。결과혈배양양성조103례，음성조273례。교지음성조，양성조적 PCT、CRP 급 NEU%수평균출현명현상승적정황，경비교차이균유통계학의의（균 P ﹤0.05）。회제 PCT、CRP 급 NEU%진단세균성혈류감염적 ROC 곡선，삼자대세균성혈류감염균구유일정적진단개치（균 P ﹤0.05）。대삼자적 ROC 곡선하면적진행량량 Z 검험비교，가득 PCT 균현저대우 CRP 화 NEU%（균 P ﹤0.05），차 CRP 여 NEU%비교차이무통계학의의（ P ﹥0.05）。연합검측여단항진단능력교고 PCT 비교령민도출현하강，단차이무통계학의의（ P ﹥0.05）；특이도상승，차차이유통계학의의（ P ﹤0.05）。작위배제표준，삼항지표균위음성시，음성예측치화특이도균체도100.0%。결론연합검측혈청 PCT、CRP 급NEU%대조기예측세균성혈류감염구유일정적적진단개치。
Objective To explore the diagnostic significance of combined detection of serum procalcitonin( PCT),C reactive protein (CRP)and neutrophil percentage(NEU% )in early prediction and diagnosis of bacterial bloodstream infection. Methods A total of 376 patients admitted in this hospital were randomly selected for thisstudy,their blood samples were examined for bacteria culture and determination of PCT, CRP and NEU% . Results The result of blood bacteria culture was positive in 103 cases(blood culture positive group)and negative in 273 ca-ses(blood culture negative group). In comparison with negative group,serum levels of PCT and CRP and percentage ofNEU% were significantly increased in positive group,and the difference was statistically significant( P ﹤ 0. 05). The ROC curves of PCT,CRP and NEU% for diagnosis of bacterial bloodstream infection had been drawn,they hadcertain value in diagnosis of bacterial bloodstream infection( P ﹤ 0. 05). The area un-der ROC curve of three items had been compared by Z test,the significance of PCT was significantly greater than that of CRP and NEU%(all P﹤ 0. 05),and the difference between NEU% and CRP was not statistically significant( P ﹥ 0. 05). In comparison with joint detection,the sig-nificance of single test of PCT with higher sensitivity was declined,but the difference was not statistically significant( P ﹥ 0. 05);but the degree of specificity raised,and the difference was statistically significant( P ﹤ 0. 05). As the exclusion criteria,when three indicators were all nega-tive,then the value of negative prediction and specificity could raise to 100% . Conclusion The significance of combined detection of serum lev-els of PCT andCRP and percentage of NEU in early diagnosis and prediction of bacterial bloodstream infection is very important.
