CAJ | 학술논문

目的：探讨急性心肌梗死患者急诊冠状动脉介入治疗围手术期大剂量阿托伐他汀的应用效果。方法回顾性分析采用急诊经皮冠状动脉介入治疗的急性心肌梗死患者60例为研究对象。30例患者围手术期采用大剂量阿托伐他汀治疗，为研究组，30例患者采用常规剂量治疗，为对照组。比较两组的临床疗效。结果研究组TIMI、TMP 3级比例显著高于对照组（P＜0.01）；CTFC显著低于对照组（P＜0.01）。研究组术后CK-MB、cTnI、hs-CRP最高值显著低于对照组，CK-MB、cTnI最高值时间显著短于对照组，2h ST段抬高恢复70%比例显著高于对照组，差异有统计学意义（P＜0.01或0.05）。结论 STEMI患者急诊PCI治疗围手术期大剂量阿托伐他汀能够显著改善术后心肌灌注。
목적：탐토급성심기경사환자급진관상동맥개입치료위수술기대제량아탁벌타정적응용효과。방법회고성분석채용급진경피관상동맥개입치료적급성심기경사환자60례위연구대상。30례환자위수술기채용대제량아탁벌타정치료，위연구조，30례환자채용상규제량치료，위대조조。비교량조적림상료효。결과연구조TIMI、TMP 3급비례현저고우대조조（P＜0.01）；CTFC현저저우대조조（P＜0.01）。연구조술후CK-MB、cTnI、hs-CRP최고치현저저우대조조，CK-MB、cTnI최고치시간현저단우대조조，2h ST단태고회복70%비례현저고우대조조，차이유통계학의의（P＜0.01혹0.05）。결론 STEMI환자급진PCI치료위수술기대제량아탁벌타정능구현저개선술후심기관주。
ObjectiveTo discuss Application of perioperative high-dose atorvastatin for STEMI patients with emergency treatment of PCI.MethodsClinical data of 60 STEMI patients with emergency treatment of PCI were respectively analyzed. 30 cases of study group was treated with perioperative high-dose atorvastatin, and 30 cased of control group was treated with conventional dose atorvastatin. Clinical efficacy of two groups was compared. ResultsTIMI, TMP 3 degree proportions of study group were higher than control group(P<0.01);CTFC of study group was lower (P<0.01). The CK-MB, cTnI, hs-CRP highest value after operation of study group was lower than control group; CK-MB, cTnI highest value of time of study group was shorter than control group; 2h ST segment elevation recovery ratio of 70% was higher than control group(P<0.01 or 0.05). Conclusion Perioperative high-dose atorvastatin for STEMI patients with emergency treatment of PCI can significant improve postoperative myocardial perfusion.