应用化工
應用化工
응용화공
Applied Chemical Industry
2015年
10期
1960-1962
,共3页
姚军%武钰%张煌涛%李东雨%鹿毅%李莉
姚軍%武鈺%張煌濤%李東雨%鹿毅%李莉
요군%무옥%장황도%리동우%록의%리리
棉酚%代谢产物%gossypolone%质谱%纯度
棉酚%代謝產物%gossypolone%質譜%純度
면분%대사산물%gossypolone%질보%순도
gossypol%metabolites%gossypolone%mass spectra%purity
以棉酚为原料，采用半合成方法，制备棉酚氧化产物 gossypolone，采用 ESI-QTOF/ MS 飞行时间质谱和 LC-MS/ MS 对产物的结构进行验证，用 HPLC 分析产物的纯度。结果显示，产物的分子量、分子式、结构式均与棉酚氧化产物 gossypolone 一致，可以推测产物为棉酚氧化产物 gossypolone，纯度≥95%。
以棉酚為原料，採用半閤成方法，製備棉酚氧化產物 gossypolone，採用 ESI-QTOF/ MS 飛行時間質譜和 LC-MS/ MS 對產物的結構進行驗證，用 HPLC 分析產物的純度。結果顯示，產物的分子量、分子式、結構式均與棉酚氧化產物 gossypolone 一緻，可以推測產物為棉酚氧化產物 gossypolone，純度≥95%。
이면분위원료，채용반합성방법，제비면분양화산물 gossypolone，채용 ESI-QTOF/ MS 비행시간질보화 LC-MS/ MS 대산물적결구진행험증，용 HPLC 분석산물적순도。결과현시，산물적분자량、분자식、결구식균여면분양화산물 gossypolone 일치，가이추측산물위면분양화산물 gossypolone，순도≥95%。
The oxidization process of gossypol was simulated by Semi-synthesis to prepare the gossypolo-ne. Then the structure of oxidization product was identified by LC-MS / MS and ESI-QTOF/ MS,the purity was analyzed by HPLC. The results indicated that the molecular weight,molecular formula,structural for-mula of product prepared in experiment were consistent with gossypolone. It can be inferred that the oxi-dization product was gossypolone,and the product content was up to 95% .
