CAJ | 학술논문

目的：探讨地西他滨治疗骨髓增生异常综合征的疗效。方法回顾性分析2012年5月～2015年5月我院收治的中、高危骨髓增生异常综合征患者63例，按照治疗方法将患者分为两组，研究组32例，对照组31例，两组在治疗期间均用相同的对症支持治疗。研究组用地西他滨治疗，对照组用传统的HA方案治疗（三尖杉酯碱及阿糖胞苷），治疗3个月后对比两组患者的临床疗效、不良反应发生率。结果研究组总有效率与对照组比较差异无统计学意义（P＞0.05），研究组不良反应总发生率与对照组比较明显较低，两组比较差异有统计学意义（P＜0.05）。结论地西他滨治疗骨髓增生异常综合征的疗效与HA方案相近，但不良反应总发生率较低，有较高的安全性，可作为一种适用骨髓增生异常综合征患者的治疗方法推荐使用。
목적：탐토지서타빈치료골수증생이상종합정적료효。방법회고성분석2012년5월～2015년5월아원수치적중、고위골수증생이상종합정환자63례，안조치료방법장환자분위량조，연구조32례，대조조31례，량조재치료기간균용상동적대증지지치료。연구조용지서타빈치료，대조조용전통적HA방안치료（삼첨삼지감급아당포감），치료3개월후대비량조환자적림상료효、불량반응발생솔。결과연구조총유효솔여대조조비교차이무통계학의의（P＞0.05），연구조불량반응총발생솔여대조조비교명현교저，량조비교차이유통계학의의（P＜0.05）。결론지서타빈치료골수증생이상종합정적료효여HA방안상근，단불량반응총발생솔교저，유교고적안전성，가작위일충괄용골수증생이상종합정환자적치료방법추천사용。
ObjectiveTo study the curative effect of decitabine in the treatment of myelodysplastic syndrome. Methods 63 patients with medium,high risk myelodysplastic syndrome,who were received and cured in our hospital from May 2012 to May 2015,were retrospectively analyzed and divided into two groups which were treated with the same symptomatic supportive treatment during the treatment period,with 32 cases in study group and 31 cases in control group.To contrast the clinical effect and the incidence of adverse reaction after treatment 3 months between the two groups,while patients in study group were treated with decitabine, and patients in control group were treated with traditional HA regimen of harringtonine and cytarabine.ResultsThe total effective rate between the two groups had little difference,there was no statistical significance(P>0.05).The overall incidence of adverse reaction in study group was obviously lower than which in control group,the difference was statistical significance(P<0.05). Conclusion Decitabine in the treatment of myelodysplastic syndrome has similar curative effect compared with HA regimen,but has lower overall incidence of adverse reaction,higher safety,could be recommended used as the treatment method on myelodysplastic syndrome.