CAJ | 학술논문

目的：探讨联合检测多种生化指标对2型糖尿病早期肾损伤的诊断价值。方法研究对象选取我院2014年1月～2015年6月192例2型糖尿病患者，其中尿微量白蛋白阴性的患者为60例设为阴性组，尿微量白蛋白阳性患者71例设为A组，临床尿蛋白阳性患者61例设为B组，同期健康体检者40例作为对照组。对四组受检者的一般资料、肾功能指标、血清胱抑素C（CysC）、血超敏C反应蛋白（hs-CRP）、同型半胱氨酸（Hcy）、尿微量白蛋白（mALB）等进行测定对比。结果三组糖尿病患者组血清CysC、hs-CRP、Hcy水平均较对照组明显升高（P＜0.05）、且A、B组患者较阴性组血清CysC、hs-CRP、Hcy水平显著升高（P＜0.05），且A、B组中三者水平与mALB正相关，随糖尿病肾病的严重程度而升高。三项联合检查的阳性率较各项单独检测的阳性率高，差异有统计学意义（P＜0.05）。结论 CysC、hs-CRP、Hcy水平与2型糖尿病患者早期肾损伤程度密切相关，其联合检测对于糖尿病肾病的早期诊断、早期治疗及监测有重要的意义。
목적：탐토연합검측다충생화지표대2형당뇨병조기신손상적진단개치。방법연구대상선취아원2014년1월～2015년6월192례2형당뇨병환자，기중뇨미량백단백음성적환자위60례설위음성조，뇨미량백단백양성환자71례설위A조，림상뇨단백양성환자61례설위B조，동기건강체검자40례작위대조조。대사조수검자적일반자료、신공능지표、혈청광억소C（CysC）、혈초민C반응단백（hs-CRP）、동형반광안산（Hcy）、뇨미량백단백（mALB）등진행측정대비。결과삼조당뇨병환자조혈청CysC、hs-CRP、Hcy수평균교대조조명현승고（P＜0.05）、차A、B조환자교음성조혈청CysC、hs-CRP、Hcy수평현저승고（P＜0.05），차A、B조중삼자수평여mALB정상관，수당뇨병신병적엄중정도이승고。삼항연합검사적양성솔교각항단독검측적양성솔고，차이유통계학의의（P＜0.05）。결론 CysC、hs-CRP、Hcy수평여2형당뇨병환자조기신손상정도밀절상관，기연합검측대우당뇨병신병적조기진단、조기치료급감측유중요적의의。
Objective To investigate joint detection of multiple biochemical indicator on the clinical diagnosis of early renal damage in type 2 diabetes mellitus.Methods 192 cases of type 2 diabetic patients from January 2014 to June 2015 were selected,including 60 cases which Microalbuminuria negative in negative group,71 cases which Microalbuminuria positive as group A,61 cases which urine proteins positive as group B,40 cases of healthy people were set as control group.The physical data,renal function,CysC,hs-CRP,Hcy,mALB levels on three groups were measured for comparison. ResultsThe CysC、hs-CRP、Hcy level of DM patients in three groups were signifintly higher than those in control group(P<0.05);The levels of CysC、hs-CRP、Hcy in group A and B were higher than negative group significantly(P<0.05),and its’ level was positively related to mALB,The positive rate of combined detection was significantly higher than the positive rate of detection of the individual, the difference was statistically significant(P<0.05).Conclusion CysC、hs-CRP、Hcy level are closely related to patients with type 2 diabetes mellitus early renal damage degree,joint detection of multiple biochemical indicator on the clinical early diagnosis,early treatment and monitoring of early renal damage in type 2 diabetes mellitus is of great significance.