中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
Chinese Journal of Behavioral Medicine and Brain Science
2015年
10期
912-914
,共3页
α-突触蛋白%A53T%帕金森病
α-突觸蛋白%A53T%帕金森病
α-돌촉단백%A53T%파금삼병
α-synuclein%A53T%Parkinson's disease
目的 分析中国人群α-突触蛋白A53T基因多态性与帕金森病(Parkinson's disease,PD)的相关性.方法 采用常规聚合酶链式反应测定224例散发性PD患者(PD组)、154例健康体检人员(对照组)的α-突触蛋白A53T基因多态性.PD患者根据Hoehn-Yahr分级(H-Y分级)标准分为H-Y≥3组(n=172)与H-Y≤2.5组(n=52).使用SPSS 19.0软件对各组基因型和等位基因频率以及A53T基因的表达与PD病情严重程度的相关性进行x2检验分析.结果 PD组与对照组A53T基因型A/A频率分别为40(17.9％)、10(6.5％)(x2=10267,P=0.001,OR=3.13,95％ CI=1.514～6.473);等位基因A频率分别为160(35.7％)、70(22.7％)(x2=14.543,P=0.000, OR=1.889,95％ CI=1.359～2.625).H-Y≥3组A53T基因型A/A频率为30(17.4％),H-Y≤2.5组A53T基因型A/A频率10(19.2％),与对照组比较,均差异有统计学意义(P=0.003,0.007);H-Y≥3组等位基因A频率为122(35.5％),H-Y≤2.5组等位基因A频率为38(36.5％),与健康对照组比较,均差异有统计学意义(P=0.000,0.006).H-Y≥3组与H-Y≤2.5组A53T基因型A/A、等位基因A频率比较,均差异无统计学意义(P=0.768,0.841).结论 中国人群中A53T基因多态性为帕金森病发病的易感因素,但其与散发性PD病情严重程度无明显相关.
目的 分析中國人群α-突觸蛋白A53T基因多態性與帕金森病(Parkinson's disease,PD)的相關性.方法 採用常規聚閤酶鏈式反應測定224例散髮性PD患者(PD組)、154例健康體檢人員(對照組)的α-突觸蛋白A53T基因多態性.PD患者根據Hoehn-Yahr分級(H-Y分級)標準分為H-Y≥3組(n=172)與H-Y≤2.5組(n=52).使用SPSS 19.0軟件對各組基因型和等位基因頻率以及A53T基因的錶達與PD病情嚴重程度的相關性進行x2檢驗分析.結果 PD組與對照組A53T基因型A/A頻率分彆為40(17.9％)、10(6.5％)(x2=10267,P=0.001,OR=3.13,95％ CI=1.514～6.473);等位基因A頻率分彆為160(35.7％)、70(22.7％)(x2=14.543,P=0.000, OR=1.889,95％ CI=1.359～2.625).H-Y≥3組A53T基因型A/A頻率為30(17.4％),H-Y≤2.5組A53T基因型A/A頻率10(19.2％),與對照組比較,均差異有統計學意義(P=0.003,0.007);H-Y≥3組等位基因A頻率為122(35.5％),H-Y≤2.5組等位基因A頻率為38(36.5％),與健康對照組比較,均差異有統計學意義(P=0.000,0.006).H-Y≥3組與H-Y≤2.5組A53T基因型A/A、等位基因A頻率比較,均差異無統計學意義(P=0.768,0.841).結論 中國人群中A53T基因多態性為帕金森病髮病的易感因素,但其與散髮性PD病情嚴重程度無明顯相關.
목적 분석중국인군α-돌촉단백A53T기인다태성여파금삼병(Parkinson's disease,PD)적상관성.방법 채용상규취합매련식반응측정224례산발성PD환자(PD조)、154례건강체검인원(대조조)적α-돌촉단백A53T기인다태성.PD환자근거Hoehn-Yahr분급(H-Y분급)표준분위H-Y≥3조(n=172)여H-Y≤2.5조(n=52).사용SPSS 19.0연건대각조기인형화등위기인빈솔이급A53T기인적표체여PD병정엄중정도적상관성진행x2검험분석.결과 PD조여대조조A53T기인형A/A빈솔분별위40(17.9％)、10(6.5％)(x2=10267,P=0.001,OR=3.13,95％ CI=1.514～6.473);등위기인A빈솔분별위160(35.7％)、70(22.7％)(x2=14.543,P=0.000, OR=1.889,95％ CI=1.359～2.625).H-Y≥3조A53T기인형A/A빈솔위30(17.4％),H-Y≤2.5조A53T기인형A/A빈솔10(19.2％),여대조조비교,균차이유통계학의의(P=0.003,0.007);H-Y≥3조등위기인A빈솔위122(35.5％),H-Y≤2.5조등위기인A빈솔위38(36.5％),여건강대조조비교,균차이유통계학의의(P=0.000,0.006).H-Y≥3조여H-Y≤2.5조A53T기인형A/A、등위기인A빈솔비교,균차이무통계학의의(P=0.768,0.841).결론 중국인군중A53T기인다태성위파금삼병발병적역감인소,단기여산발성PD병정엄중정도무명현상관.
Objective To investigate the association of α-synaptophysin A53T gene polymorphism with parkinson's disease(PD) in Chinese people.Methods The conventional polymerase chain reaction was used to detect the α-synaptophysin A53T gene polymorphism in 224 sporadic PD patients(PD group)and 154 healthy individuals(control group).According to the Hoehn-Yahr(H-Y) classification standard, PD patients were divided into H-Y ≥ 3 group(n=172) and H-Y ≤ 2.5 group(n=52).Each genotype and alleles frequencies as well as the A53T gene expression and their relation to the severity of parkinson's disease were analyzed with Chi-square test of SPSS19.0.Results The frequency of the A53T genotype of A/A were 40(17.9％) and 10(6.5％) (x2 =10.267, P=0.001, OR=3.13,95％ CI =1.514-6.473) in the PD group and control group, respectively.The frequency of the allele A was 160(35.7％) and 70(22.7％) (x2 =14.543, P=0.000, OR=1.889,95％ CI =1.359-2.625) in the PD group and control group,respectively.The frequency of the A53T genotype of A/A was 30(17.4％) and l0 (19.2％) in the H-Y ≥ 3 group and H-Y ≤ 2.5 group, respectively, with significant difference (P=0.003,0.007) as compared to the control group.The frequency of the allele A was 122(35.5％) and 38(36.5％) in the the H-Y ≥ 3 group and H-Y ≤ 2.5 group,respectively, with significant difference (P=0.000,0.006) as compared to the control group.There was no statistically significant difference of the A53T genotype of A/A and the allele A between the H-Y≥3 group and H-Y≤2.5 group (P=0.768,0.841).Conclusion The A53T gene polymorphism is the risk factor of Parkinson's disease in Chinese people, but it isn't correlated to stage of sporadic parkinson' s disease.
