中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2015年
10期
900-903
,共4页
王运红%周琼%安涛%张荣成%黄燕%甘天翊%梁拓%赵雪梅%刘妮妮
王運紅%週瓊%安濤%張榮成%黃燕%甘天翊%樑拓%趙雪梅%劉妮妮
왕운홍%주경%안도%장영성%황연%감천익%량탁%조설매%류니니
心血管疾病%生物学标记%参考值
心血管疾病%生物學標記%參攷值
심혈관질병%생물학표기%삼고치
Cardiovascular diseases%Biological markers%Reference values
目的 探讨北京地区社区人群可溶性ST2(sST2)的血浆水平及其影响因素,建立健康社区人群sST2血浆水平的正常参考值范围.方法 2012年3至8月入选社区健康人1 334名,其中男性597名,女性737名.留取血浆标本,采用酶联免疫吸附法,测定sST2血浆水平.采用经验法和分位数回归法估计健康社区人群sST2血浆水平的范围,建立多重线性回归模型分析影响健康人sST2血浆水平的因素.结果 性别是影响健康人sST2血浆水平的重要因素,总体男性sST2血浆水平明显高于女性(P＜0.01),经年龄分层后,各年龄段(＜ 45岁、45～54岁、55～ 64岁、≥65岁)男性sST2血浆水平仍均明显高于女性(P均＜0.01).年龄、体质指数(body mass index,BMI)、收缩压、舒张压、吸烟不影响sST2血浆水平.经验法计算的男性sST2血浆水平参考值范围为5.7～53.5 μg,/L,女性为4.4～42.4 μg/L(95％非参数参考值范围).单侧第95百分位上限男性为47.2 μg/L,女性为37.2 μg/L,可作为区分心血管疾病状态与正常人的界限.结论 本研究初步建立了中国北京地区健康人sST2血浆水平的正常参考值范围.性别是影响健康人sST2血浆水平的主要因素.
目的 探討北京地區社區人群可溶性ST2(sST2)的血漿水平及其影響因素,建立健康社區人群sST2血漿水平的正常參攷值範圍.方法 2012年3至8月入選社區健康人1 334名,其中男性597名,女性737名.留取血漿標本,採用酶聯免疫吸附法,測定sST2血漿水平.採用經驗法和分位數迴歸法估計健康社區人群sST2血漿水平的範圍,建立多重線性迴歸模型分析影響健康人sST2血漿水平的因素.結果 性彆是影響健康人sST2血漿水平的重要因素,總體男性sST2血漿水平明顯高于女性(P＜0.01),經年齡分層後,各年齡段(＜ 45歲、45～54歲、55～ 64歲、≥65歲)男性sST2血漿水平仍均明顯高于女性(P均＜0.01).年齡、體質指數(body mass index,BMI)、收縮壓、舒張壓、吸煙不影響sST2血漿水平.經驗法計算的男性sST2血漿水平參攷值範圍為5.7～53.5 μg,/L,女性為4.4～42.4 μg/L(95％非參數參攷值範圍).單側第95百分位上限男性為47.2 μg/L,女性為37.2 μg/L,可作為區分心血管疾病狀態與正常人的界限.結論 本研究初步建立瞭中國北京地區健康人sST2血漿水平的正常參攷值範圍.性彆是影響健康人sST2血漿水平的主要因素.
목적 탐토북경지구사구인군가용성ST2(sST2)적혈장수평급기영향인소,건립건강사구인군sST2혈장수평적정상삼고치범위.방법 2012년3지8월입선사구건강인1 334명,기중남성597명,녀성737명.류취혈장표본,채용매련면역흡부법,측정sST2혈장수평.채용경험법화분위수회귀법고계건강사구인군sST2혈장수평적범위,건립다중선성회귀모형분석영향건강인sST2혈장수평적인소.결과 성별시영향건강인sST2혈장수평적중요인소,총체남성sST2혈장수평명현고우녀성(P＜0.01),경년령분층후,각년령단(＜ 45세、45～54세、55～ 64세、≥65세)남성sST2혈장수평잉균명현고우녀성(P균＜0.01).년령、체질지수(body mass index,BMI)、수축압、서장압、흡연불영향sST2혈장수평.경험법계산적남성sST2혈장수평삼고치범위위5.7～53.5 μg,/L,녀성위4.4～42.4 μg/L(95％비삼수삼고치범위).단측제95백분위상한남성위47.2 μg/L,녀성위37.2 μg/L,가작위구분심혈관질병상태여정상인적계한.결론 본연구초보건립료중국북경지구건강인sST2혈장수평적정상삼고치범위.성별시영향건강인sST2혈장수평적주요인소.
Objective This study was designed to investigate the plasma level of soluble ST2 (sST2) and related influencing factors, and establish its reference value in the healthy community-based population in Beijing area of China.Methods We measured plasma sST2 level by enzyme-linked immunosorbent assay between March 2012 and August 2012 in 1 334 healthy subjects in communities, including 597 males and 737 females.Empiric and quantile regression methods were used to determine the reference range of plasma sST2.A multiple linear regression model was established to analyze the factors that might affect the level of plasma sST2.Results Gender is the most important factor affecting the plasma level of sST2 in healthy people.Plasma level of sST2 is significantly higher in men than in women (P ＜ 0.01).Within each age strata, i.e.＜ 45, 45-54, 55-64, ≥ 65 years old, the plasma levels of sST2 were significantly higher in men than age-matched female (all P ＜0.01).Age, body mass index (BMI), systolic blood pressure, diastolic blood pressure, and smoking did not affect plasma sST2 level.Reference range of sST2 was 5.7-53.5 μg/L for men and 4.4-42.4 μg/L for women (95％ nonparametric reference interval).The one-side upper 95th percentile value of sST2 to discriminate the cardiovascular disease from healthy state was 47.2 μg/L for men and 37.2 μg/L for women.Conclusions This study established the normal reference range of plasma sST2 in healthy community-based population.The major influencing factor of sST2 level in healthy population is gender.
