CAJ | 학술논문

目的：采用免疫组化染色法分析多效生长因子（PTN）和基质金属蛋白酶2（MMP2）在浸润性乳腺癌中的表达与病理特征。方法选取2011年10月至2014年10月诊治的浸润性乳腺癌患者138例，其中三阴性乳腺癌患者69例，非三阴性乳腺癌患者69例。取22例癌旁组织作为对照。采用免疫组化染色法测定 PTN、MMP2在浸润性乳腺癌中表达情况。结果三阴性乳腺癌患者与非三阴性乳腺癌患者在年龄、肿瘤直径、腋窝淋巴结转移情况上差异无统计学意义（ P ﹥0.05）。三阴性乳腺癌患者与非三阴性乳腺癌患者在肿瘤分级上差异有统计学意义（ P ﹤0.05）。PTN 阳性表达率为84.8%（117/138），MMP2阳性表达率为73.9%（102/138）。PTN 阳性表达与 MMP2阳性表达多见于三阴性乳腺癌患者、40~59岁患者、肿瘤直径3~5 cm 患者、肿瘤分级Ⅱ~Ⅲ级患者、腋窝淋巴结转移患者。PTN、MMP2与浸润性乳腺癌均呈明显正相关性。结论 PTN、MMP2在浸润性乳腺癌中呈高表达。肿瘤分级越高，PTN 与 MMP2的阳性表达越高。
목적：채용면역조화염색법분석다효생장인자（PTN）화기질금속단백매2（MMP2）재침윤성유선암중적표체여병리특정。방법선취2011년10월지2014년10월진치적침윤성유선암환자138례，기중삼음성유선암환자69례，비삼음성유선암환자69례。취22례암방조직작위대조。채용면역조화염색법측정 PTN、MMP2재침윤성유선암중표체정황。결과삼음성유선암환자여비삼음성유선암환자재년령、종류직경、액와림파결전이정황상차이무통계학의의（ P ﹥0.05）。삼음성유선암환자여비삼음성유선암환자재종류분급상차이유통계학의의（ P ﹤0.05）。PTN 양성표체솔위84.8%（117/138），MMP2양성표체솔위73.9%（102/138）。PTN 양성표체여 MMP2양성표체다견우삼음성유선암환자、40~59세환자、종류직경3~5 cm 환자、종류분급Ⅱ~Ⅲ급환자、액와림파결전이환자。PTN、MMP2여침윤성유선암균정명현정상관성。결론 PTN、MMP2재침윤성유선암중정고표체。종류분급월고，PTN 여 MMP2적양성표체월고。
Objective To explore the pathological features and expression of PTN and MMP2 in patients with invasive breast cancer by immunohistochemical staining. Methods A total of 138 patients with invasive breast cancer in this hospital during October 2011 to October 2014 were allocated in this study,among them 69 patients were suffered from breast cancer with three negative makers,69 patients were suffered from breast cancer without three negative markers,and 22 cases of tumor adjacent tissue were used as controls. The expression of PTNand MMP2 in in-vasive breast cancer was detected by immunohistochemical staining. Results There was no significant difference in age,tumor size,metastasis in axillary lymph nodes between breast cancer with three negative markers and breast cancer without 3 negative markers( P ﹥ 0. 05). There was sig-nificant difference in tumor gradesbetween breast cancer with 3 negative markers and breast cancer without 3 negative markers( P ﹤ 0. 05). The positiverate of PTN expression was 84. 8%(117 / 138). The positive rate of expression of MMP2 was 73. 9%(102 / 138). Thepositive expression of PTN and positive rate of expression of MMP2 were found in patients with breast cancer having 3 negative markers,40 ~ 59 years old,with tumor diameter of 3 ~ 5 cm,tumor grading at II ~ III grades,and metastasis inaxillary lymph nodes. The expression of PTN and MMP2 had significant positive correlation with the degree ofinvasive breast cancer. Conclusion High expressions of PTN and MMP2 have been seen in patients with in-vasive breast cancer. When the grade of tumor is higher,then the positive expression of PTN and MMP2 will be higher.