CAJ | 학술논문

目的：探讨降钙素原（PCT）与 C 反应蛋白（CRP）对支气管哮喘急性发作患儿细菌性感染的诊断价值。方法临床纳入支气管哮喘急性发作患儿70例，根据诱发因素分为过敏组（22例）、病毒感染组（17例）以及细菌感染组（31例）。分别采集上述各组患儿静脉血，采用免疫荧光法检测血清 PCT 水平，采用酶联免疫吸附法检查血清 CRP 水平。比较各组 PCT、CRP 水平和阳性率，并分析 PCT 与 CRP 的相关性。结果细菌感染组血清 PCT、CRP 水平分别为（25.9±11.3）μg/ L、（50.5±17.6）mg/ L，病毒感染组血清 PCT、CRP 水平分别为（0.8±0.3）μg/ L、（6.2±0.4）mg/ L，过敏组血清 PCT、CRP 水平分别为（0.3±0.2）μg/ L、（3.6±0.5）mg/ L。其中，细菌感染组血糖 PCT、CRP 水平明显高于病毒感染者与过敏组，差异均有显著性（ P ﹤0.05）；细菌感染组血清 PCT 与 CRP 水平呈现正相关（ r =3.610，P ﹤0.05）；病毒感染组及过敏组血清 PCT 与 CRP 水平则无相关性（ P ﹥0.05）；以 PCT≥0.5μg/ L，CRP≥10 mg/ L 为阳性标准，细菌感染组血清 PCT、CRP 阳性率分别为93.55%、90.32%，病毒感染组血清 PCT、CRP 阳性率分别为64.71%、29.41%，过敏组血清 PCT、CRP 阳性率分别为31.82%、22.73%。细菌感染组血清 PCT、CRP 阳性率明显高于病毒感染者与过敏组，差异均有显著性（ P ﹤0.05）。结论血清 PCT 与 CRP 水平能够鉴别细菌性感染诱发的支气管哮喘急性发作，能够为临床指导抗生素的应用提供依据。
목적：탐토강개소원（PCT）여 C 반응단백（CRP）대지기관효천급성발작환인세균성감염적진단개치。방법림상납입지기관효천급성발작환인70례，근거유발인소분위과민조（22례）、병독감염조（17례）이급세균감염조（31례）。분별채집상술각조환인정맥혈，채용면역형광법검측혈청 PCT 수평，채용매련면역흡부법검사혈청 CRP 수평。비교각조 PCT、CRP 수평화양성솔，병분석 PCT 여 CRP 적상관성。결과세균감염조혈청 PCT、CRP 수평분별위（25.9±11.3）μg/ L、（50.5±17.6）mg/ L，병독감염조혈청 PCT、CRP 수평분별위（0.8±0.3）μg/ L、（6.2±0.4）mg/ L，과민조혈청 PCT、CRP 수평분별위（0.3±0.2）μg/ L、（3.6±0.5）mg/ L。기중，세균감염조혈당 PCT、CRP 수평명현고우병독감염자여과민조，차이균유현저성（ P ﹤0.05）；세균감염조혈청 PCT 여 CRP 수평정현정상관（ r =3.610，P ﹤0.05）；병독감염조급과민조혈청 PCT 여 CRP 수평칙무상관성（ P ﹥0.05）；이 PCT≥0.5μg/ L，CRP≥10 mg/ L 위양성표준，세균감염조혈청 PCT、CRP 양성솔분별위93.55%、90.32%，병독감염조혈청 PCT、CRP 양성솔분별위64.71%、29.41%，과민조혈청 PCT、CRP 양성솔분별위31.82%、22.73%。세균감염조혈청 PCT、CRP 양성솔명현고우병독감염자여과민조，차이균유현저성（ P ﹤0.05）。결론혈청 PCT 여 CRP 수평능구감별세균성감염유발적지기관효천급성발작，능구위림상지도항생소적응용제공의거。
Objective To study the diagnostic value of serum procalcitonin(PCT)and C - reactive protein(CRP)for bacterial infection in children with acute bronchial asthma. Methods Seventy children with acute bronchial asthma were selected and divided into allergic group(22 cases),virus infection group(17 cases)and bacterial infection group(31 cases)according to precipitating factors. The venous blood was collect-ed. The level of PCT based on immunofluorescence method and the level of CRP based on enzyme linked immunosorbent assay were detected. The level and positive rate of PCT and CRP of each group was analyzed;the correlation of PCT with CRP was studied. Results The levels of PCT and CRP were(25. 9 ± 11. 3)μg/ L and(50. 5 ± 17. 6)mg/ L,respectively in bacterial infection group,they were(0. 8 ± 0. 3)μg/ L and(6. 2 ± 0. 4)mg/ L respectively in virus infection group,and(0. 3 ± 0. 2)μg/ L and(3. 6 ± 0. 5)mg/ L respectively in allergic group. The levels of PCT and CRP in bacterial infection group were significantly higher than those in virus infection group and allergic group( P ﹤ 0. 05). For bacterial in-fection group,PCT level and CRP level had a positive correlation( r = 3. 610,P ﹤ 0. 05);however,no such correlation was found in virus infec-tion group and allergic group( P ﹥ 0. 05). According to the positive criteria of PCT≥0. 5 μg/ L and CRP≥10 mg/ L,the positive rates of PCT and CRP of bacterial infection group were respectively 93. 55% and 90. 32% ,they were respectively 64. 71% and 29. 41% in virus infection group and 31. 82% and 22. 73% in allergic group. The positive rates of PCT and CRP of bacterial infection group were significantly higher than those of virus infection group and allergic group( P ﹤ 0. 05). Conclusion Serum levels of PCT and CRP are applicable to identify the acute bronchial asthma caused by bacterial infection and provide the guidance for antibiotic application in clinical practice.