CAJ | 학술논문

维生素 D3的经典作用是调节体内钙、磷的代谢平衡和维持骨的健康，有证据显示维生素 D3也可调节动物生殖。维生素 D 代谢酶可合成和降解活性维生素 D3及其代谢中间产物，活性维生素 D3通过结合至目标组织的维生素 D 受体（vitamin D receptor，VDR）以发挥其生物学作用。VDR和维生素 D 代谢酶在雄性生殖系统中表达，表明维生素 D3在雄性生殖生物学中起关键作用。本文对维生素 D3与雄性生殖的研究进展作一综述，以期为推进维生素 D3影响雄性生殖的分子机制和临床治疗男性不育的研究提供理论依据。
유생소 D3적경전작용시조절체내개、린적대사평형화유지골적건강，유증거현시유생소 D3야가조절동물생식。유생소 D 대사매가합성화강해활성유생소 D3급기대사중간산물，활성유생소 D3통과결합지목표조직적유생소 D 수체（vitamin D receptor，VDR）이발휘기생물학작용。VDR화유생소 D 대사매재웅성생식계통중표체，표명유생소 D3재웅성생식생물학중기관건작용。본문대유생소 D3여웅성생식적연구진전작일종술，이기위추진유생소 D3영향웅성생식적분자궤제화림상치료남성불육적연구제공이론의거。
The classical effects of vitamin D3 are modulating calcium and phosphorus metabolic balance and maintaining bone health in vivo.It has been shown that vitamin D3 could regulate animal reproduc-tion.Vitamin D metabolic enzymes synthesize and degrade active vitamin D3 and its metabolic intermedi-ates,and active vitamin D3 exerts its biological effects through binding to vitamin D receptor (VDR). VDR and vitamin D metabolic enzymes expressed in male reproductive system,it suggest that vitamin D3 plays a pivotal role in male reproductive biology.In this review,we mainly focus on the progress of vita-min D3 and male reproduction to provide a theoretical basis for pushing forward the molecular mechanisms research of vitamin D3 effects on male reproduction and clinical therapy for male infertility.