CAJ | 학술논문

目的：探讨儿童消化性溃疡患者与食物特异性 IgG 的相关性，评估忌食不耐受食物在消化性溃疡治疗中的作用。方法：采用酶联免疫吸附法（ELISA）检测69例儿童消化性溃疡患者血清14种食物特异性IgG ，分析患者对不同食物不耐受的分布情况及其与年龄、性别以及不同部位溃疡的关系；并将有食物特异性IgG升高的65例患者分为观察组（35例）和对照组（30例），观察组忌食不耐受食物，8周复查胃镜，与未限制饮食的对照组比较溃疡治愈情况。结果：消化性溃疡患者食物特异性 IgG 升高65例，阳性率为94．2％。学龄前患者牛奶和鸡蛋不耐受率均高，学龄期和青春期患者鸡蛋不耐受率最高，随着年龄的增大，不耐受的食物种类增多。治疗8周复查胃镜，观察组溃疡痊愈率较对照组高。结论：儿童消化性溃疡患者体内食物特异性IgG阳性率较高，提示消化性溃疡可能与食物不耐受有关，不耐受食物种类与年龄有关，与性别及溃疡部位无明显关系，忌食不耐受食物可提高溃疡痊愈率。
목적：탐토인동소화성궤양환자여식물특이성 IgG 적상관성，평고기식불내수식물재소화성궤양치료중적작용。방법：채용매련면역흡부법（ELISA）검측69례인동소화성궤양환자혈청14충식물특이성IgG ，분석환자대불동식물불내수적분포정황급기여년령、성별이급불동부위궤양적관계；병장유식물특이성IgG승고적65례환자분위관찰조（35례）화대조조（30례），관찰조기식불내수식물，8주복사위경，여미한제음식적대조조비교궤양치유정황。결과：소화성궤양환자식물특이성 IgG 승고65례，양성솔위94．2％。학령전환자우내화계단불내수솔균고，학령기화청춘기환자계단불내수솔최고，수착년령적증대，불내수적식물충류증다。치료8주복사위경，관찰조궤양전유솔교대조조고。결론：인동소화성궤양환자체내식물특이성IgG양성솔교고，제시소화성궤양가능여식물불내수유관，불내수식물충류여년령유관，여성별급궤양부위무명현관계，기식불내수식물가제고궤양전유솔。
Objective To discuss the relationship between peptic ulcer in children and food-specific IgG, and to evaluate the effect of avoiding the intolerant food on treatment of peptic ulcer. Method Fourteen kinds of food specific IgG in 69 cases of peptic ulcer were tested by ELISA. The patient′s intolerance to different foods and its relationship with age , sex and different ulcer were analyzed. The efficacy of avoiding the intolerant food was assessed after 8 weeks. Results Total positive of food-specific IgG in children with peptic ulcer was 94.2%. For preschool children, the highest intolerance rates were in milk and eggs; for school-age and adolescence children, the highest intolerance rate was in eggs. As the age increases, kinds of intolerant food increased too. Ulcer healing rate in observation group was higher than that in the control group after 8 weeks. Conclusions High positive percentage of food- specific IgG was found in children with peptic ulcer , indicating a possible correlation of peptic ulcer and food-intolerance. Kinds of intolerant food correlates with the age group , but not with sex and ulcer sites. Avoiding the intolerant food may increase ulcer healing rate.