CAJ | 학술논문

目的：初步探讨创伤后应激障碍（PTSD）患者血清中白细胞介素（IL）-1、IL-6、肿瘤坏死因子－α（TNF-α）与环氧化酶－2（COX-2）的表达变化及意义。方法：收集32例PTSD患者（PTSD组）与26例健康体检者（对照组），采用酶联免疫吸附法（ELISA）与Western blot法对PTSD组血清中IL-1、IL-6、TNF-α及COX-2进行检测，并与对照组进行比较。结果：PTSD 组血清 IL-1、IL-6及 TNF-α水平明显高于对照组（P ＜0．01）；COX-2含量水平也明显高于对照组（P ＜0．01）。结论：PTSD患者存在显著的免疫功能紊乱，IL-1、IL-6、TNF-α及COX-2可能在PTSD的发病机制中起着重要作用。
목적：초보탐토창상후응격장애（PTSD）환자혈청중백세포개소（IL）-1、IL-6、종류배사인자－α（TNF-α）여배양화매－2（COX-2）적표체변화급의의。방법：수집32례PTSD환자（PTSD조）여26례건강체검자（대조조），채용매련면역흡부법（ELISA）여Western blot법대PTSD조혈청중IL-1、IL-6、TNF-α급COX-2진행검측，병여대조조진행비교。결과：PTSD 조혈청 IL-1、IL-6급 TNF-α수평명현고우대조조（P ＜0．01）；COX-2함량수평야명현고우대조조（P ＜0．01）。결론：PTSD환자존재현저적면역공능문란，IL-1、IL-6、TNF-α급COX-2가능재PTSD적발병궤제중기착중요작용。
Objective To investigate the significance of variation of concentrations of serum IL-1,IL-6, TNF-α and cyclooxygenase-2 in patients with post-traumatic stress disorder (PTSD). Methods Thirty-two PTSD patients were chosen as the observation group and another 26 normal patients were taken as the control group. The concentrations of serum IL-1,IL-6,TNF-α and COX-2 in patients of both groups were detected by Enzyme-linked immunosorbent assay (ELISA) and Western blot and were compared in these 2 groups. Results The concentrations of serum IL-1 , IL-6 and TNF-α were significantly higher in the observation group than those in the control group (P < 0.01);and the level of COX-2 in the observation group was significantly higher than that of the control group(P < 0.01). Conclusions Abnormal immune states are awared in PTSD patients and the IL-1,IL-6,TNF-α and COX-2 might play an important role in the pathogenesis of PTSD.