CAJ | 학술논문

目的：探讨肺结核复治涂阳患者采用联合左氧氟沙星化疗的临床疗效。方法：采用随机数字表法将我院第二门诊2012年10月至2014年10月收治的60例肺结核复治涂阳患者分为左氧氟沙星组和常规治疗组各30例，常规治疗组采用含利福平的抗结核方案，左氧氟沙星组在常规组基础上加用左氧氟沙星治疗，两组疗程均为9个月，比较两组患者的疗效及不良反应差异。结果：左氧氟沙星组在第6、9个月的阴转率分别为93．33％、96．67％，显著高于常规组的70％和73．33％（P ＜0．05）。左氧氟沙星组病灶吸收显著优于常规治疗组（P ＜0．05）。左氧氟沙星组的空洞改善率为73．33％，显著高于常规治疗组的33．33％（P ＜0．05）。左氧氟沙星组的临床疗效分布显著优于常规治疗组（P ＜0．05），左氧氟沙星组的总有效率达到100％，显著优于常规治疗组的86．67％（P ＜0．05）。结论：左氧氟沙星联合常规抗结核化疗方案可以有效提高抗结核治疗的临床效果。
목적：탐토폐결핵복치도양환자채용연합좌양불사성화료적림상료효。방법：채용수궤수자표법장아원제이문진2012년10월지2014년10월수치적60례폐결핵복치도양환자분위좌양불사성조화상규치료조각30례，상규치료조채용함리복평적항결핵방안，좌양불사성조재상규조기출상가용좌양불사성치료，량조료정균위9개월，비교량조환자적료효급불량반응차이。결과：좌양불사성조재제6、9개월적음전솔분별위93．33％、96．67％，현저고우상규조적70％화73．33％（P ＜0．05）。좌양불사성조병조흡수현저우우상규치료조（P ＜0．05）。좌양불사성조적공동개선솔위73．33％，현저고우상규치료조적33．33％（P ＜0．05）。좌양불사성조적림상료효분포현저우우상규치료조（P ＜0．05），좌양불사성조적총유효솔체도100％，현저우우상규치료조적86．67％（P ＜0．05）。결론：좌양불사성연합상규항결핵화료방안가이유효제고항결핵치료적림상효과。
Objective Investigate the clinical efficacy of treating retreated smear-positive tuberculosis patients with conventional anti-tuberculosis chemotherapy combined with levofloxacin. Methods Divide 60 retreated smear-positive tuberculosis patients registered in our hospital between October 2012 and October 2014 into two groups using random number table method: levofloxacin group and conventional treatment group. Each group contains 30 patients that were treated for 9 months , and the efficacy the both treatment methods were compared. Results The sputum conversion rate in the levofloxacin group is 93.33% and 96.67% after treating for 6 months and 9 months , respectively; which are substantial higher than that of the conventional treatment group with sputum conversion rate of 70% and 73.33% after 6 months and 9 months of treatment , respectively (P < 0.05). The absorption rate of the levofloxacin group is significantly higher than that of the conventional treatment group (P < 0.05). The cavity improvement rate of the levofloxacin group is 73.33%, which is significantly higher than that of the conventional treatment group (33.33%) (P < 0.05). The clinical efficacy of the LVFX group is substantially higher than the routine treatment group (P < 0.05). The overall effectiveness of LVFX group reached 100% , which is significantly higher than that of the conventional treatment group (86.67%) (P < 0.05). Conclusions Levofloxacin combined with conventional anti-tuberculosis chemotherapy can effectively improve the clinical efficacy in the treatment of tuberculosis.