中外医学研究
中外醫學研究
중외의학연구
Chinese and Foreign Medical Research
2015年
31期
6-7,8
,共3页
何建明%朱明霞%许虹%杨东仪%韦柳梅
何建明%硃明霞%許虹%楊東儀%韋柳梅
하건명%주명하%허홍%양동의%위류매
急性脑梗死%纤维蛋白原功能%低分子肝素钙
急性腦梗死%纖維蛋白原功能%低分子肝素鈣
급성뇌경사%섬유단백원공능%저분자간소개
Acute cerebral infarction%Fibrinogen function%Low Molecular Weight Heparin Calcium
目的：探讨急性脑梗死患者血浆纤维蛋白原(Fg)功能水平在不同时间段的变化及低分子肝素钙治疗对其的影响。方法：选择100例脑梗死患者(脑梗死组)，按照随机数字表法分为抗凝组和非抗凝组，各50例，并设立对照组50例，抗凝组给予低分子肝素钙治疗，分别于第1、10天检测Fg水平，并比较两组的临床疗效。结果：脑梗死组两个时间点血浆Fg的水平明显高于对照组(P<0.01)；抗凝组和非抗凝组治疗前后Fg水平比较，治疗前两组比较差异无统计学意义(P>0.05)，治疗后抗凝组明显降低，两组比较差异有统计学意义(P<0.01)；应用低分子肝素干预治疗10 d后，抗凝组总有效率为92%，非抗凝组总有效率为48%，两组比较差异有统计学意义(P<0.05)。结论：急性脑梗死后血浆Fg水平明显增高，应用低分子肝素抗凝治疗能降低患者血凝状态，且能提高临床疗效。
目的：探討急性腦梗死患者血漿纖維蛋白原(Fg)功能水平在不同時間段的變化及低分子肝素鈣治療對其的影響。方法：選擇100例腦梗死患者(腦梗死組)，按照隨機數字錶法分為抗凝組和非抗凝組，各50例，併設立對照組50例，抗凝組給予低分子肝素鈣治療，分彆于第1、10天檢測Fg水平，併比較兩組的臨床療效。結果：腦梗死組兩箇時間點血漿Fg的水平明顯高于對照組(P<0.01)；抗凝組和非抗凝組治療前後Fg水平比較，治療前兩組比較差異無統計學意義(P>0.05)，治療後抗凝組明顯降低，兩組比較差異有統計學意義(P<0.01)；應用低分子肝素榦預治療10 d後，抗凝組總有效率為92%，非抗凝組總有效率為48%，兩組比較差異有統計學意義(P<0.05)。結論：急性腦梗死後血漿Fg水平明顯增高，應用低分子肝素抗凝治療能降低患者血凝狀態，且能提高臨床療效。
목적：탐토급성뇌경사환자혈장섬유단백원(Fg)공능수평재불동시간단적변화급저분자간소개치료대기적영향。방법：선택100례뇌경사환자(뇌경사조)，안조수궤수자표법분위항응조화비항응조，각50례，병설립대조조50례，항응조급여저분자간소개치료，분별우제1、10천검측Fg수평，병비교량조적림상료효。결과：뇌경사조량개시간점혈장Fg적수평명현고우대조조(P<0.01)；항응조화비항응조치료전후Fg수평비교，치료전량조비교차이무통계학의의(P>0.05)，치료후항응조명현강저，량조비교차이유통계학의의(P<0.01)；응용저분자간소간예치료10 d후，항응조총유효솔위92%，비항응조총유효솔위48%，량조비교차이유통계학의의(P<0.05)。결론：급성뇌경사후혈장Fg수평명현증고，응용저분자간소항응치료능강저환자혈응상태，차능제고림상료효。
Objective:To investigate the changes of Plasma fibrinogen function levels at different time periods in patients with acute cerebral infarction,and their changses in response to Low Molecular Weight Heparin Calcium treatment.Method:100 cases of cerebral infarction were randomly divided into anticoagulant group and non-anticoagulant group,50 cases in each group,and establish health group 50 peoples(the control group), Anticoagulant group were treated with Low Molecular Weight Heparin Calcium .We’ve detected that Plasma fibrinogen function levels in 1,10 d,and the clinical efficacy of two groups were compared.Result:Cerebral infarction group at two time points of plasma Fg levels were significantly higher than those of the control group(P<0.01). Compare anticoagulation group and control group before and after treatment Fg level,no difference before treatment(P>0.05), after treatment,the anticoagulant group was significantly lower,there was significant difference(P<0.01).Low Molecular Weight Heparin Calcium for 10 days after the intervention,the total effective rate of the anticoagulant group(92%) was higher than that of the non-anticoagulant group(48%),the difference was statistically significant(P<0.05).Conclusion:Fg plasma after acute cerebral infarction are significantly increased,Low Molecular Weight Heparin anticoagulant therapy can reduce blood clotting status of patients,and it can improve the clinical efficacy.
