实用医学杂志
實用醫學雜誌
실용의학잡지
The Journal of Practical Medicine
2015年
18期
2969-2971
,共3页
曹旭%吴冀川%李蓬秋%张学军%鲜杨%包明晶%杨艳%邓君%房俊
曹旭%吳冀川%李蓬鞦%張學軍%鮮楊%包明晶%楊豔%鄧君%房俊
조욱%오기천%리봉추%장학군%선양%포명정%양염%산군%방준
糖尿病,2型%颈动脉中层厚度%糖化血清白蛋白%GA/HbA1c比值
糖尿病,2型%頸動脈中層厚度%糖化血清白蛋白%GA/HbA1c比值
당뇨병,2형%경동맥중층후도%당화혈청백단백%GA/HbA1c비치
Diabetes,type 2%Carotid intima-media thickness%Glycated albumin%GA/HbA1c ratio
目的：评价GA／HbA1c 比值与2型糖尿病颈动脉粥样硬化斑块相关性。方法：选取四川省人民医院内分泌科住院的2型糖尿病患者，收集临床数据进行分析。结果：纳入154例患者，相关分析显示GA／HbA1c比值与体质指数、血尿酸呈负相关；与年龄、同型半胱氨酸、空腹血糖、餐后血糖、左和右侧颈动脉中层厚度呈正相关。其中颈动脉斑块阳性组与阴性组相比，GA、GA／HbA1c 比值及同型半胱氨酸水平前者显著高于后者。 Logistic回归分析显示GA／HbA1c比值是影响2型糖尿病患者发生颈动脉粥样硬化斑块的独立危险因素（P ＝0．008）。结论：GA／HbA1c比值与2型糖尿病患者颈动脉中层厚度呈正相关。这提示GA／HbA1c比值能作为预测糖尿病患者心血管并发症的潜在临床指标。
目的：評價GA／HbA1c 比值與2型糖尿病頸動脈粥樣硬化斑塊相關性。方法：選取四川省人民醫院內分泌科住院的2型糖尿病患者，收集臨床數據進行分析。結果：納入154例患者，相關分析顯示GA／HbA1c比值與體質指數、血尿痠呈負相關；與年齡、同型半胱氨痠、空腹血糖、餐後血糖、左和右側頸動脈中層厚度呈正相關。其中頸動脈斑塊暘性組與陰性組相比，GA、GA／HbA1c 比值及同型半胱氨痠水平前者顯著高于後者。 Logistic迴歸分析顯示GA／HbA1c比值是影響2型糖尿病患者髮生頸動脈粥樣硬化斑塊的獨立危險因素（P ＝0．008）。結論：GA／HbA1c比值與2型糖尿病患者頸動脈中層厚度呈正相關。這提示GA／HbA1c比值能作為預測糖尿病患者心血管併髮癥的潛在臨床指標。
목적：평개GA／HbA1c 비치여2형당뇨병경동맥죽양경화반괴상관성。방법：선취사천성인민의원내분비과주원적2형당뇨병환자，수집림상수거진행분석。결과：납입154례환자，상관분석현시GA／HbA1c비치여체질지수、혈뇨산정부상관；여년령、동형반광안산、공복혈당、찬후혈당、좌화우측경동맥중층후도정정상관。기중경동맥반괴양성조여음성조상비，GA、GA／HbA1c 비치급동형반광안산수평전자현저고우후자。 Logistic회귀분석현시GA／HbA1c비치시영향2형당뇨병환자발생경동맥죽양경화반괴적독립위험인소（P ＝0．008）。결론：GA／HbA1c비치여2형당뇨병환자경동맥중층후도정정상관。저제시GA／HbA1c비치능작위예측당뇨병환자심혈관병발증적잠재림상지표。
Objective To investigate the association between the glycated albumin to glycated hemoglobin (GA/A1c) ratio and carotid plaque. Methods Type 2 diabetic (T2DM) patients in endocrine inpatient department of Sichuan Provincial People′s Hospital were chosen whose clinical data were collected. Results Of the recruited 154 T2DM patients , GA/HbA1c ratio was negatively correlated with BMI , blood uric acid and was positively correlated with age, HCY, FBG, PBG, left carotid IMT and right carotid IMT. In terms of carotid plaque, GA, GA/HbA1c ratio and HCY were higher in carotid plaque positive patients than those without carotid plaque. The results of logistic regression analysis showed that GA/HbA1c ratio was significantly associated with the presence of carotid plaque (P=0.008). Conclusions GA/HbA1c ratio was positively correlated with the presence of carotid artery IMT in T2DM This suggests that GA/HbA1c ratio will serve as a useful clinical marker for predicting diabetic cardiovascular complications.
