CAJ | 학술논문

目的：探讨 NADPH 氧化酶 p22phox 亚基（NADPH oxidase subunit p22phox，NOSP）C242T 基因多态性与中国朝鲜族人群原发性高血压（EH）患者发生左心室肥厚（LVH）的相关性。方法：选取正常朝鲜族对照者108例及初诊为EH朝鲜族患者231例，应用聚合酶链反应对所有受试者NOSP 242位点进行基因型分析。231例EH 患者再分为EH 和EH＋LVH 组，超声心动图评估患者左心室质量指数，并测定生化指标。结果：NOSP 242位点基因多态性在对照组和 EH 组中的分布无明显差异；EH 组和 EH＋LVH 组中，CC 与CT＋TT比较，基因分布存在明显差异；CC型EH 患者合并LVH 的风险高于CT及TT型患者。结论： NOSP C242T基因多态性与朝鲜族EH患者无关。 NOSP C242T 基因多态性与EH 合并LVH 相关，CC基因是朝鲜族EH患者合并LVH的风险因素。
목적：탐토 NADPH 양화매 p22phox 아기（NADPH oxidase subunit p22phox，NOSP）C242T 기인다태성여중국조선족인군원발성고혈압（EH）환자발생좌심실비후（LVH）적상관성。방법：선취정상조선족대조자108례급초진위EH조선족환자231례，응용취합매련반응대소유수시자NOSP 242위점진행기인형분석。231례EH 환자재분위EH 화EH＋LVH 조，초성심동도평고환자좌심실질량지수，병측정생화지표。결과：NOSP 242위점기인다태성재대조조화 EH 조중적분포무명현차이；EH 조화 EH＋LVH 조중，CC 여CT＋TT비교，기인분포존재명현차이；CC형EH 환자합병LVH 적풍험고우CT급TT형환자。결론： NOSP C242T기인다태성여조선족EH환자무관。 NOSP C242T 기인다태성여EH 합병LVH 상관，CC기인시조선족EH환자합병LVH적풍험인소。
Objective To investigate the relation between the NOSP gene C242T polymorphism and Chinese Korean nationality EH patients with LVH. Methods 108 Chinese Korean controls and 231 Chinese Korean EH patients were enrolled in the research.NOSP gene C242T polymorphism was analyzed by PCR. EH patients were divided into EH and EH+LVH group,all of them were evaluated with CDUS for left ventricular mass index. Results The distribution of NOSP gene C242T polymorphism showed no significant difference compared with controls and EH group.There was significant difference in distribution of CC vs CT+TT genotype between EH and EH+ LVH patients.CC genotype is more dangerous for EH patients combined with LVH than CT and TT genotypes. Conclusions The NOSP gene C242T polymorphism has no relation with EH in Korean nationality people. The NOSP gene C242T polymorphism has relation with EH+LVH; and the CC genotype is a susceptible gene for the Korean EH patients with LVH.