CAJ | 학술논문

目的：观察充血性心力衰竭患者外周血中淋巴细胞表面CD54、CD106的变化情况。方法：采用流式细胞仪技术对心衰组、单纯高血压组、单纯扩张型心肌病组、健康志愿者的外周血中淋巴细胞表面 CD54及CD106的百分率进行检测及应用彩色多普勒超声心动图对心衰患者分别于心衰发作期及缓解期测定心脏功能。结果：外周血淋巴细胞表面CD54、CD106在单纯高血压组、高血压性心脏病伴心衰发作组及高血压性心脏病伴心衰缓解组分别与健康对照组相比差异均有显著性；外周血淋巴细胞表面CD54、CD106在单纯扩张型心肌病组、扩张型心肌病伴心衰发作组、扩张型心肌病伴心衰缓解组分别与健康对照组相比差异均有显著性；外周血淋巴细胞表面CD54、CD106随着心衰程度的加重而增加，且差异均有显著性；心衰患者的LVEF与外周血淋巴细胞表面CD54呈显著负相关。结论：CD54、CD106对判断或监测心衰患者病情进展及活动转归具有一定意义。
목적：관찰충혈성심력쇠갈환자외주혈중림파세포표면CD54、CD106적변화정황。방법：채용류식세포의기술대심쇠조、단순고혈압조、단순확장형심기병조、건강지원자적외주혈중림파세포표면 CD54급CD106적백분솔진행검측급응용채색다보륵초성심동도대심쇠환자분별우심쇠발작기급완해기측정심장공능。결과：외주혈림파세포표면CD54、CD106재단순고혈압조、고혈압성심장병반심쇠발작조급고혈압성심장병반심쇠완해조분별여건강대조조상비차이균유현저성；외주혈림파세포표면CD54、CD106재단순확장형심기병조、확장형심기병반심쇠발작조、확장형심기병반심쇠완해조분별여건강대조조상비차이균유현저성；외주혈림파세포표면CD54、CD106수착심쇠정도적가중이증가，차차이균유현저성；심쇠환자적LVEF여외주혈림파세포표면CD54정현저부상관。결론：CD54、CD106대판단혹감측심쇠환자병정진전급활동전귀구유일정의의。
Objective To study the expression changes of CD54 and CD106 in peripheral blood lymphocyte in patients with congest heart failure. Methods With FCM technique, the levels of CD54 and CD106 in lymphocyte from patients with CHF were measured , and those of patients with hypertension , patients with dilated cardiomyopathy and normal controls were measured at the same time. Cardiac function during heart failure episodes and remission stage was monitored by Color Doppler Echocardiography. Results Levels of CD54 and CD106 were significantly elevated in patients with hypertension , patients with active CHF and hypertension , patients with inactive CHF and hypertension when compared with those of normal controls. Levels of CD54 and CD106 were significantly elevated in patients of dilated cardiomyopathy , patients with active CHF and dilated cardiomyopathy , patients with inactive CHF and dilated cardiomyopathy when compared with those of normal controls. Levels of CD54 and CD106 in patients of CHF were elevated with the degree of CHF. There was significantly negative correlation between LVEF and CD54 of CHF. Conclusions CD54 and CD106 may use as the marker to monitor the progress of CHF.