CAJ | 학술논문

目的：通过检测喘息患儿FcεRI－β基因多态性与临床表现及哮喘相关性的研究，探讨该基因多态性对喘息患儿的易感性与预后的作用。方法：选取住院喘息患儿146例，用荧光定量PCR法检测患儿FcεRI－β基因，其中 AG 、GG 为风险基因型，共41例，AA 为正常基因型，共105例；记录两组患儿的喘息发作程度；出院后随访2年，记录两组患儿的哮喘发病率。结果：风险型基因组与正常型基因组在喘息发作严重程度中的分布差异有统计学意义（P ＝0．003），风险型基因组较正常型基因组喘息发作严重；两组患儿在随访2年后，哮喘发病率上比较差异没有统计学意义（P ＝0．13）。结论：FcεRI－β基因多态性与患儿的喘息发病相关，风险型基因是喘息发生的危险因素；风险型基因影响喘息发作的严重程度；但不是发生哮喘的主导因素。
목적：통과검측천식환인FcεRI－β기인다태성여림상표현급효천상관성적연구，탐토해기인다태성대천식환인적역감성여예후적작용。방법：선취주원천식환인146례，용형광정량PCR법검측환인FcεRI－β기인，기중 AG 、GG 위풍험기인형，공41례，AA 위정상기인형，공105례；기록량조환인적천식발작정도；출원후수방2년，기록량조환인적효천발병솔。결과：풍험형기인조여정상형기인조재천식발작엄중정도중적분포차이유통계학의의（P ＝0．003），풍험형기인조교정상형기인조천식발작엄중；량조환인재수방2년후，효천발병솔상비교차이몰유통계학의의（P ＝0．13）。결론：FcεRI－β기인다태성여환인적천식발병상관，풍험형기인시천식발생적위험인소；풍험형기인영향천식발작적엄중정도；단불시발생효천적주도인소。
Objective To investigate the correlations of FcεRI-βgene polymorphisms with clinical manifestation and prognosis inwheezing infants. Methods One hundred and forty-six wheezing infants were recruited and divided into two groups by FcεRI-βdetection using Fluorescent quantitative PCR: Risk genotype group (n = 41) or normal genotype group (n = 105). The genotype distributions,clinical manifestation and asthma,and morbidity were analyzed and compared between the two groups. Results FcεR1 E237G AG/GG was more serious than FcεR1 AA in wheezing infants. (χ2 = 14.202; P = 0.003). No significant differences were found in AS morbidity between the two groups after two years follow-up (χ2 = 2.25;P = 0.13). Conclusion FcεRI-βgene polymorphisms are strongly related with infantile wheezing. Th risk genotype may be the severity of asthma but may not be the major influencing factor of asthma.