癌症进展
癌癥進展
암증진전
Oncology Progress
2015年
5期
504-511
,共8页
周立莉%葛新国%蔡茂怀%唐峰%朱建峰%孙林%李霞%刘菊林%王彩莲
週立莉%葛新國%蔡茂懷%唐峰%硃建峰%孫林%李霞%劉菊林%王綵蓮
주립리%갈신국%채무부%당봉%주건봉%손림%리하%류국림%왕채련
ETS-1%黏蛋白类%波形蛋白%非小细胞肺癌%肿瘤转移
ETS-1%黏蛋白類%波形蛋白%非小細胞肺癌%腫瘤轉移
ETS-1%점단백류%파형단백%비소세포폐암%종류전이
ETS-1%mucins%vimentin%non-small cell lung cancer%neoplasms metastasis
目的:探讨ETS-1与E-cadherin、N-cadherin、Vimentin在肺癌中的表达相关性及其临床意义。方法选择接受手术切除并经病理证实的110例非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的肿瘤组织和距肿瘤3 cm以上的癌旁正常肺组织,采用免疫组化SP法检测组织中ETS-1与E-cadherin、N-cadherin、Vimen-tin的表达,并结合临床资料进行相关性分析。结果非小细胞肺癌组织中ETS-1与N-cadherin、Vimentin的阳性表达率分别为65%(72/110)、56%(62/110)、34%(37/110),明显高于正常癌旁肺组织的6%(3/50)、8%(4/50)、2%(1/50),组间差异具有统计学意义(P<0.01);E-cadherin的阳性表达率为41%(45/110),明显低于正常癌旁肺组织中的84%(42/50)。ETS-1的阳性率与淋巴结转移和TNM分期呈正相关(P<0.05),而与性别、年龄、肿瘤直径、组织学类型及分化程度无关(P>0.05)。E-cadherin的阳性率与肿瘤分化程度、淋巴结转移和TNM分期呈负相关(P<0.05),N-cadherin和Vimentin的阳性率与肿瘤分化程度、淋巴结转移及TNM分期呈正相关(P<0.05),E-cadherin、N-cadherin、Vimentin的表达与患者的性别、年龄、肿瘤直径、组织学类型无相关性(P>0.05)。在非小细胞肺癌中ETS-1与E-cadherin的表达呈负相关,ETS-1与N-cadherin的表达呈正相关。结论 ETS-1与E-cadherin、N-cadherin、Vimentin的表达和非小细胞肺癌的转移密切相关,其检测可作为判断非小细胞肺癌转移和预后的指标之一。
目的:探討ETS-1與E-cadherin、N-cadherin、Vimentin在肺癌中的錶達相關性及其臨床意義。方法選擇接受手術切除併經病理證實的110例非小細胞肺癌(non-small cell lung cancer,NSCLC)患者的腫瘤組織和距腫瘤3 cm以上的癌徬正常肺組織,採用免疫組化SP法檢測組織中ETS-1與E-cadherin、N-cadherin、Vimen-tin的錶達,併結閤臨床資料進行相關性分析。結果非小細胞肺癌組織中ETS-1與N-cadherin、Vimentin的暘性錶達率分彆為65%(72/110)、56%(62/110)、34%(37/110),明顯高于正常癌徬肺組織的6%(3/50)、8%(4/50)、2%(1/50),組間差異具有統計學意義(P<0.01);E-cadherin的暘性錶達率為41%(45/110),明顯低于正常癌徬肺組織中的84%(42/50)。ETS-1的暘性率與淋巴結轉移和TNM分期呈正相關(P<0.05),而與性彆、年齡、腫瘤直徑、組織學類型及分化程度無關(P>0.05)。E-cadherin的暘性率與腫瘤分化程度、淋巴結轉移和TNM分期呈負相關(P<0.05),N-cadherin和Vimentin的暘性率與腫瘤分化程度、淋巴結轉移及TNM分期呈正相關(P<0.05),E-cadherin、N-cadherin、Vimentin的錶達與患者的性彆、年齡、腫瘤直徑、組織學類型無相關性(P>0.05)。在非小細胞肺癌中ETS-1與E-cadherin的錶達呈負相關,ETS-1與N-cadherin的錶達呈正相關。結論 ETS-1與E-cadherin、N-cadherin、Vimentin的錶達和非小細胞肺癌的轉移密切相關,其檢測可作為判斷非小細胞肺癌轉移和預後的指標之一。
목적:탐토ETS-1여E-cadherin、N-cadherin、Vimentin재폐암중적표체상관성급기림상의의。방법선택접수수술절제병경병리증실적110례비소세포폐암(non-small cell lung cancer,NSCLC)환자적종류조직화거종류3 cm이상적암방정상폐조직,채용면역조화SP법검측조직중ETS-1여E-cadherin、N-cadherin、Vimen-tin적표체,병결합림상자료진행상관성분석。결과비소세포폐암조직중ETS-1여N-cadherin、Vimentin적양성표체솔분별위65%(72/110)、56%(62/110)、34%(37/110),명현고우정상암방폐조직적6%(3/50)、8%(4/50)、2%(1/50),조간차이구유통계학의의(P<0.01);E-cadherin적양성표체솔위41%(45/110),명현저우정상암방폐조직중적84%(42/50)。ETS-1적양성솔여림파결전이화TNM분기정정상관(P<0.05),이여성별、년령、종류직경、조직학류형급분화정도무관(P>0.05)。E-cadherin적양성솔여종류분화정도、림파결전이화TNM분기정부상관(P<0.05),N-cadherin화Vimentin적양성솔여종류분화정도、림파결전이급TNM분기정정상관(P<0.05),E-cadherin、N-cadherin、Vimentin적표체여환자적성별、년령、종류직경、조직학류형무상관성(P>0.05)。재비소세포폐암중ETS-1여E-cadherin적표체정부상관,ETS-1여N-cadherin적표체정정상관。결론 ETS-1여E-cadherin、N-cadherin、Vimentin적표체화비소세포폐암적전이밀절상관,기검측가작위판단비소세포폐암전이화예후적지표지일。
Objective To observe the expression between ETS-1 and neuronal cadherin (E-cadherin, N-cadherin) and Vimentin in non-small cell lung cancer (NSCLC) tissues and to study the clinical correlation of those molecules. Method 110 cases of NSCLC patients who had undergone surgical resection were confirmed pathologically and were included in this study, of which the tumor tissues and normal lung tissues that were at least 3 cm away from the tumor were selected. The immunohistochemistry SP method was used to detect the expression of ETS-1, E-cadherin, N-cadherin and Vimentin, then the correlation was investigated. Result In NSCLC tissues, the positive expression rate of ETS-1, N-cadherin and Vimentin [65%(72/110), 56%(62/110), and 34%(37/110), respectively] were significant-ly higher than those in normal lung tissues [6%(3/50), 8%(4/50), 2%(1/50), respectively] (all P<0.01); The positive expression rate of E-cadherin was 41%(45/110), which was significantly lower than the 84%(42/50) of normal lung tissues. The expression of ETS-1 was positively correlated with the lymph node metastasis and TNM staging (P<0.05), but was not associated with gender, age, tumor diameter, histological type and differentiation degree (P>0.05). The expression of E-cadherin was negatively correlated with tumor differentiation degree, the lymph node metastasis and TNM staging (P<0.05). The expression of N-cadherin and Vimentin were positively correlated with tumor differ-entiation degree, the lymph node metastasis and TNM staging (P<0.05). The expression of E-cadherin, N-cadherin and Vimentin were not correlated with gender, age, tumor diameter and histological type (P>0.05). While the expres-sion of ETS-1 was negatively correlated with E-cadherin but positively correlated with N-cadherin in NSCLC. Con-clusion The expression of ETS-1, E-cadherin, N-cadherin and Vimentin are closely related with metastasis of NSCLC, thus the detection on the expression of those molecules will be effective in estimating the metastasis and prognosis of NSCLC.