癌症进展
癌癥進展
암증진전
Oncology Progress
2015年
5期
561-564
,共4页
胃癌%晚期%NLR%预测价值
胃癌%晚期%NLR%預測價值
위암%만기%NLR%예측개치
gastric cancer%late%NLR%predictive value
目的：探讨中性粒细胞与淋巴细胞比值（neutrophil to lymphocyte ratio，NLR）对晚期胃癌患者预后的预测价值。方法选取72例接受胃癌根治术的晚期胃癌患者作为研究对象，根据血细胞分类计数计算NLR ，将53例NLR＜3的患者列为低NLR组；19例NLR≥3的患者列为高NLR组，分析两组患者的临床病理特征和预后。结果高NLR组中浸润深度为T3、T4期患者的比例占89.47%，淋巴结转移中N1、N2、N3的比例占63.16%，远处转移中M1的比例为15.79%；低NLR组中浸润深度为T3、T4期患者的比例占77.36%，淋巴结转移中N1、N2、N3的比例占50.94%，远处转移中M1的比例为7.55%。由此，高NLR组中出现浸润深度、淋巴结转移、远处转移的例数明显高于低NLR组，差异有统计学意义（P＜0.05）；低NLR组和高NLR组的5年生存率（58.49% vs 42.11%）及无病生存率（73.58% vs 57.89%）差异显著，均具有统计学意义（P＜0.05）。结论高NLR可作为晚期胃癌患者生存率、无病生存率的独立危险因素，并对评估患者的预后具有重要的预测作用。
目的：探討中性粒細胞與淋巴細胞比值（neutrophil to lymphocyte ratio，NLR）對晚期胃癌患者預後的預測價值。方法選取72例接受胃癌根治術的晚期胃癌患者作為研究對象，根據血細胞分類計數計算NLR ，將53例NLR＜3的患者列為低NLR組；19例NLR≥3的患者列為高NLR組，分析兩組患者的臨床病理特徵和預後。結果高NLR組中浸潤深度為T3、T4期患者的比例佔89.47%，淋巴結轉移中N1、N2、N3的比例佔63.16%，遠處轉移中M1的比例為15.79%；低NLR組中浸潤深度為T3、T4期患者的比例佔77.36%，淋巴結轉移中N1、N2、N3的比例佔50.94%，遠處轉移中M1的比例為7.55%。由此，高NLR組中齣現浸潤深度、淋巴結轉移、遠處轉移的例數明顯高于低NLR組，差異有統計學意義（P＜0.05）；低NLR組和高NLR組的5年生存率（58.49% vs 42.11%）及無病生存率（73.58% vs 57.89%）差異顯著，均具有統計學意義（P＜0.05）。結論高NLR可作為晚期胃癌患者生存率、無病生存率的獨立危險因素，併對評估患者的預後具有重要的預測作用。
목적：탐토중성립세포여림파세포비치（neutrophil to lymphocyte ratio，NLR）대만기위암환자예후적예측개치。방법선취72례접수위암근치술적만기위암환자작위연구대상，근거혈세포분류계수계산NLR ，장53례NLR＜3적환자렬위저NLR조；19례NLR≥3적환자렬위고NLR조，분석량조환자적림상병리특정화예후。결과고NLR조중침윤심도위T3、T4기환자적비례점89.47%，림파결전이중N1、N2、N3적비례점63.16%，원처전이중M1적비례위15.79%；저NLR조중침윤심도위T3、T4기환자적비례점77.36%，림파결전이중N1、N2、N3적비례점50.94%，원처전이중M1적비례위7.55%。유차，고NLR조중출현침윤심도、림파결전이、원처전이적례수명현고우저NLR조，차이유통계학의의（P＜0.05）；저NLR조화고NLR조적5년생존솔（58.49% vs 42.11%）급무병생존솔（73.58% vs 57.89%）차이현저，균구유통계학의의（P＜0.05）。결론고NLR가작위만기위암환자생존솔、무병생존솔적독립위험인소，병대평고환자적예후구유중요적예측작용。
Objective To investigate the neutrophil to lymphocyte ratio (NLR) predictive value in patients with advanced gastric cancer prognosis. Method Patients with advanced gastric cancer between 72 routine gastrectomy as the research object, and calculates the NLR in accordance with peripheral blood cell count, and 33 cases of NLR<3 patients classified as low NLR group, 19 patients classified as high NLR≥3 NLR group, clinical features and progno-sis of patients two groups of patients were analyzed, analysis of neutrophil-lymphocyte ratio prognostic value in pa-tients with advanced gastric cancer. Result The depth of invasion NLR group T3, T4 ratio of 89.47%, lymph node metastasis N1, N2, N3 ratio of 63.16%, distant metastasis M1 ratio was 15.79%, the low NLR group, depth of invasion, T3, T4 ratio of 77.36%, lymph node transfer proportion of N1, N2, N3 of 50.94%, distant metastasis M1 ratio of 7.55%, higher NLR group depth of invasion, lymph node metastasis, distant metastasis was significantly higher than the low NLR group, the difference was statistically significant(P<0.05). Low NLR group of 5-year survival rate was signifi-cantly higher than 58.49% 42.11% higher NLR group, the difference was statistically significant(P<0.05). Low NLR group of disease-free survival rate 73.58%(39/53) was significantly higher than the high NLR group 57.89%(11/19), the difference was statistically significant(P<0.05). Conclusion NLR as advanced gastric cancer patients survival, disease-free survival as an independent risk factor, and its value for the prognosis of patients with advanced gastric cancer has an important predictive value.
