CAJ | 학술논문

目的：探讨单纯性肥胖症儿童促酰化蛋白（ASP）和脂联素（ADPN）水平变化的临床意义。方法选取2014年1月至2014年12月惠州市第一妇幼保健院儿科内分泌门诊就诊及健康体检的200例儿童作为研究对象，其中单纯性肥胖组62例，超重组73例和健康对照组65例。根据患者的身高和体质量计算出体质量指数（BMI）。测定空腹血糖（FPG）、空腹胰岛素（FINS）、总胆固醇（ TC）、三酰甘油（TG）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）、促酰化蛋白（ASP）和脂联素（ADPN）。结果与健康对照组比较，肥胖组和超重组的 FPG、FINS、LDL-C、TC、TG、ASP和胰岛素抵抗指数（IRI）均升高（P ＜0.05）；HDL-C、ADPN和胰岛素敏感指数（ISI）均降低（P ＜0.05）。与超重组比较，肥胖组的 FPG、FINS、LDL-C、TC、TG、ASP和 IRI均升高，差异有统计学意义（P ＜0.05）；HDL-C、ADPN和 ISI显著降低（P ＜0.05）。血清 ASP和 ADPN的浓度变化呈负相关。结论单纯性肥胖症儿童体内脂肪细胞因子ASP水平显著升高，而ADPN显著降低，并与BMI、血脂代谢及胰岛抵抗密切相关。
목적：탐토단순성비반증인동촉선화단백（ASP）화지련소（ADPN）수평변화적림상의의。방법선취2014년1월지2014년12월혜주시제일부유보건원인과내분비문진취진급건강체검적200례인동작위연구대상，기중단순성비반조62례，초중조73례화건강대조조65례。근거환자적신고화체질량계산출체질량지수（BMI）。측정공복혈당（FPG）、공복이도소（FINS）、총담고순（ TC）、삼선감유（TG）、저밀도지단백（LDL-C）、고밀도지단백（HDL-C）、촉선화단백（ASP）화지련소（ADPN）。결과여건강대조조비교，비반조화초중조적 FPG、FINS、LDL-C、TC、TG、ASP화이도소저항지수（IRI）균승고（P ＜0.05）；HDL-C、ADPN화이도소민감지수（ISI）균강저（P ＜0.05）。여초중조비교，비반조적 FPG、FINS、LDL-C、TC、TG、ASP화 IRI균승고，차이유통계학의의（P ＜0.05）；HDL-C、ADPN화 ISI현저강저（P ＜0.05）。혈청 ASP화 ADPN적농도변화정부상관。결론단순성비반증인동체내지방세포인자ASP수평현저승고，이ADPN현저강저，병여BMI、혈지대사급이도저항밀절상관。
Objective To explore the relationship between acylation stimulating protein(ASP),adiponectin(ADPN)and the inci-dence of childhood obesity and the significance of them in diagnoses and therapy of children's obesity. Methods 200 children including 62 obese children,73 overweight children and 65 healthy control children were recruited. Fasting plasma glucose (FPG),fasting insulin (FINS),total cholesterol(TC),triglyeerides (TG),low density lipoprotein-cholesterol (LDL-C),and HDL-C (high density lipoprotein-cholesterol)were determined by automatic blood analyses machine. Serum ASP and ADPN levels were determined by enzyme linked immu-nosorbent assay(ELISA). Results Compared with healthy children group,FPG,FINS,LDL-C,TC,TG,insulin resistance index(IRI), ASP of obese and overweight children groups were significantly higher(P < 0. 05),while the level of HDL-C,ADPN and insulin sensitivity index(ISI)were significantly lower(P < 0. 05). And there was significant difference in the levels of FPG,FINS,LDL-C,TC,TG and IRI between obese and overweight children groups(P < 0. 05). ASP was negatively connected with ADPN in neonates with HIE. Conclusion In simple obesity children,there was a significant change in serum ASP and ADPN. And ASP and ADPN were involved in the disorder of lipid metabolism in obese children. Serum ASP and ADPN levels can be used as a new indicator to evaluate the risk of childhood obesity trends and future evaluation of diabetes and cardiovascular diseases.