CAJ | 학술논문

目的：探讨血清 S100B蛋白和神经元特异性烯醇化酶（NSE）在新生儿缺氧缺血性脑病（HIE）早期诊断及判断预后的应用价值。方法选取2010年1月至2014年12月深圳市儿童医院新生儿科住院的 HIE的患儿和健康新生儿作为研究对象。健康对照组40例，HIE组97例，其中轻度组41例，中度组30例，重度组26例。入组的新生儿均于出生后的第1、3、7天晨起空腹时采集静脉血测定血清S100蛋白和 NSE 含量。结果 HIE 组患儿各个时间点 S100B 蛋白和 NSE 含量均明显高于健康对照组（P均＜0.05）。治疗前中、重度组血清 S100B蛋白和 NSE含量明显高于轻度组（P ＜0.05）经治疗后血清 S100B蛋白和 NSE含量均明显下降（P均＜0.05）。血清 S100B蛋白含量与 NSE含量呈正相关（P ＜0.05）。结论血清 S100B蛋白和 NSE在 HIE的早期诊断、损伤程度及预后的判断有重要意义。
목적：탐토혈청 S100B단백화신경원특이성희순화매（NSE）재신생인결양결혈성뇌병（HIE）조기진단급판단예후적응용개치。방법선취2010년1월지2014년12월심수시인동의원신생인과주원적 HIE적환인화건강신생인작위연구대상。건강대조조40례，HIE조97례，기중경도조41례，중도조30례，중도조26례。입조적신생인균우출생후적제1、3、7천신기공복시채집정맥혈측정혈청S100단백화 NSE 함량。결과 HIE 조환인각개시간점 S100B 단백화 NSE 함량균명현고우건강대조조（P균＜0.05）。치료전중、중도조혈청 S100B단백화 NSE함량명현고우경도조（P ＜0.05）경치료후혈청 S100B단백화 NSE함량균명현하강（P균＜0.05）。혈청 S100B단백함량여 NSE함량정정상관（P ＜0.05）。결론혈청 S100B단백화 NSE재 HIE적조기진단、손상정도급예후적판단유중요의의。
Objective To evaluate the diagnosis of protein S100B and neurone specific enolase(NSE)in neonates with hypoxic-is-chemic encephalopathy(HIE). Methods The data of 137 neonates hospitalized in our hospital,including 40 healthy neonates,41 neonates with mild HIE,30 neonates with medium HIE and 26 neonates with severe HIE,from Jan. 2010 to Dec. 2014 were analyzed retrospectively. The levels of protein S100B and NSE were detected in all newborn infants on the 1d,3d and 7d after birth. Results Compared with healthy neonates group,protein S100B and NSE in HIE groups were significantly higher (P < 0. 05). The levels of protein S100B and NSE were all significantly decreased after treatment. The relationship between protein S100B and NSE in neonates with HIE was positively correlated. Conclusion Protein S100B and NSE are good biomarkers for the early identification of HIE,its extent of damage and the prognosis.